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A STUDY OF LIPID COMPONENTS IN BRAIN OF THE ‘JIMPY’ MOUSE, A MUTANT WITH MYELIN DEFICIENCY (1969)

Nussbaum, J. L. ; Neskovic, N. ; Mandel, P.

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 16 (1969), S. 0

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ISSN: 1471-4159

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: (1) Brain composition and developmental changes were investigated in a mutant (‘Jimpy’) mouse characterized by a severe myelin deficiency.(2) Significantly lower cholesterol, phospholipid and galactolipid values were observed, and the accumulation of these lipids during the myelination period was markedly reduced or absent.(3) The most remarkable feature of ‘Jimpy’ brain was a very small galactolipid content. In 29-day-old mutants the concentration of galactolipids was 0-18 μ moles/g wet wt., representing a 46-fold decrease when compared to values determined in normal mice.(4) There was no such striking change in the distribution of different phospholipids. However, lowered relative amounts of some phospholipids, e.g. ethanolamine plasmalogen, sphingomyelin and phosphatidylserine, were observed in ‘Jimpy’ brain.(5) Protein content was also lower in mutant brains and showed an absolute decrease after 23 days of life.(6) These data support the statement that the process of myelination is disturbed at an early stage, resulting in a deficiency of mature myelin sheaths and leading probably to the breakdown of primitive myelin structures.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb08982.x

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Rainbows with a Si thin crystal (2000)

Neskovic, N. ; Petrovic, S. ; Zivkovic, L.

Springer

The European physical journal 18 (2000), S. 553-558

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ISSN: 1434-6036

Keywords: PACS. 61.85.+p Channeling phenomena (blocking, energy loss, etc.) - 02.40.-k Geometry, differential geometry, and topology

Source: Springer Online Journal Archives 1860-2000

Topics: Physics

Notes: Abstract: This study is devoted to the transmission of Ne10+ ions through a Si thin crystal. The ion energy is 60 MeV and the crystal thickness is varied from 159 to 478 atomic layers, i.e. within the first rainbow cycle. The analysis is performed by the theory of crystal rainbows. The angular distribution of the transmitted ions is generated by the computer simulation method. Then, the rainbow lines in the scattering angle plane are determined. These lines ensure the full explanation of the angular distribution.