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  • 1965-1969  (2)
  • 1
    Electronic Resource
    Electronic Resource
    EFFECT OF IONS ON STIMULUS-INDUCED RELEASE OF AMINO ACIDS FROM MAMMALIAN BRAIN SLICES (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Slices of mammalian brain accumulate amino acids contained in physiological medium. When such tissues were subjected to mild electrical stimulation of short duraation capable of depolarizing neural membranes, there occurred a striking increase in the efflux of exogenous amino acids. The effects on representative acidic, neutral, and basic amino acids were similar. Elevated levels of potassium chloride evoked release of amino acids comparable to electrical stimulation. Electrically stimulated release of [3H]γ-aminobutyric acid was not inhibited by the presence of reduced concentrations of calcium ions. Although amino acids are actively accumulated by liver and kidney slices, electrical stimulation of these tissues failed to release these compounds. Stimulation-induced release was significantly diminished by the presence of small amounts of lithium in the perfusing medium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb08986.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    RELEASE OF [3H]SEROTONIN FROM BRAIN SLICES (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Labelled serotonin ([3H]5-HT) accumulated by slices of rat brain either in vivo or in vitro is released by depolarizing procedures such as electrical stimulation or high external potassium concentrations. Electrical stimulation predominantly affects the liberation of the unchanged amine, rather than of its principal metabolite, 5-HIAA.2. Release of [3H]5-HT does not appear to be calcium-dependent.3. Amount of release parallels the density of serotonin-containing nerve terminals in each of several cerebral regions tested. Release from several extracerebral tissues was similar to that obtained from cerebral tissues having relatively little endogenous 5-HT.4. Electrically induced release of [3H]5-HT is markedly inhibited by desipramine, chlorpromazine, LSD, lithium and ouabain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb06860.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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