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  • 1990-1994  (5)
  • 1960-1964  (6)
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  • 1
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Twenty-eight cases of monocytoid B-cell lymphoma of lymph nodes and 16 lymph node metastases of primary gastric lymphomas, mostly low-grade B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) type were investigated morphologically and immunohistochemically. Both groups showed the same morphological and immunohistochemical features: diagnostically important sites of infiltration were the sinuses and the marginal zones, The tumour cells were either medium-sized or small. The cytoplasm stained grey with Giemsa and was sometimes rather pale. In imprints the grey colour of the cytoplasm was a characteristic feature. The medium-sized cell type was more frequent; in one third of the cases it was combined with a prominent lymphoplasmacytic component from the same clone, and it resembled the monocytoid B-cells of the sinuses. The small cell type was less common, was not combined with a lymphoplasmacytic component and more closely resembled marginal zone cells. The difference was underlined by the negative reaction with the monoclonal antibody Ki-B3 in the small cell type, which, conversely, was positive in the medium-sized cell type and in the monocytoid B-cell reaction of the sinuses. Both of these cell types, however, showed a granular reaction with the new monoclonal antibody Ki-Mlp. The morphological and immunohistochemical parallels are arguments in favour of the assumption that monocytoid B-cell lymphoma is the nodal equivalent of low-grade B-cell lymphoma of MALT type. This is further supported by the fact that in nine of our 28 cases of monocytoid B-cell lymphoma, lymphomas were found simultaneously or subsequently in organs of the MALT. Monocytoid B-cell lymphoma must be differentiated from an infiltration that occurs in the form of clusters of monocytoid B-cells in other low-grade B-cell lymphomas, especially in immunocytoma with a high content of epithelioid cells.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 16 (1990), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sixty-two cases of primary malignant lymphoma of the were investigated. Fifty-eight lymphomas were of B- and two of T-cell type. Two cases of high-grade homa could not be further classified. The largest group (43 cases) consisted of low-grade B-cell lymphoma of the bronchus-associated lymphoid tissue. These showed features similar to low-grade B-cell lymphomas of the mucosa-associated lymphoid tissue of the stomach. The low-grade lymphomas showed a peak occurrence in the sixth decade, the high-grade lymphomas in venth decade. Males predominated slightly. Three-quarters of the patients with low-grade B-cell lymphoma of the bronchus-associated lymphoid tissue showed solitary or multiple sharply defined nodules of the lung. The prognosis of the B-cell-derived lung lymphomas without constitutional symptoms was relatively favourable, regardless of whether they were of low- or high-grade malignancy, whereas patients with constitutional symptoms and the two patients with T-cell lymphomas showed a bad prognosis. However, recurrences and metastases in the lung, stomach, lymph nodes and salivary glands were seen in about 46% of the cases of low-grade B-cell lymphoma of the bronchus-associated lymphoid tissue.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 21 (1992), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lymph nodes from 21 cases of generalized mastocytosis were studied histologically to confirm or exclude mast cell infiltration, and to investigate their micro-architecture. Mast cell infiltrates were detected in 17 (80%) of the lymph nodes and were found mainly in the medullary cords and sinuses. Diffuse infiltration was seen in 14 cases and focal infiltration in three cases. The following pathological findings were frequently observed: germinal centre hyperplasia (n= 14), which is probably a nonspecific finding; and hyperplasia of small blood vessels, which sometimes resembled high endothelial venules (14), eosinophilia (8), plasmacytosis (7) and collagen fibrosis (6), all of which may well be related to the effects of mediators released by mast cells. Infiltrates of acute or chronic myeloid leukaemia were seen in six lymph nodes. Division of the cases into two prognostically different groups, i.e. systemic mastocytosis, in which the skin lesions of urticaria pigmentosa are present and the prognosis is favourable, and malignant mastocytosis, in which there is no cutaneous involvement and the prognosis is poor, revealed that all six lymph nodes exhibiting leukaemic infiltrates came from the malignant mastocytosis group; eosinophilia, plasmacytosis and fibrosis were seen significantly more often in malignant than in systemic mastocytosis, but blood vessel hyperplasia and germinal centre hyperplasia were encountered with the same high frequency in both groups; and mast cell atypia tended to be more pronounced in malignant mastocytosis; this diagnosis could therefore easily be missed without naphthol AS-D chloroacetate esterase staining. In four lymph nodes no mast cell infiltrates could be detected, although two of these exhibited eosinophilia, plasmacytosis and fibrosis. As only one example of the lymphadenopathic variant of generalized mastocytosis was found amongst 181 archive and published cases reviewed, this would appear to be very rare.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 24 (1994), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Amongst a total of 329 cases of low-grade B-cell lymphoma of Waldeyer's ring, we identified 12 cases that corresponded histomorphologically to low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type. These lymphomas are characterized by an extrafollicular growth pattern, often with a marginal zone-like arrangement, and by the centrocyte-like morphology of the tumour cells. They have not been described previously in this location. They predominantly affected the palatine tonsil. Ten cases were primary lymphomas of Waldeyer's ring. In two cases there was a simultaneous high-grade component. Two cases showed regional spread to cervical lymph nodes, but there was no widespread nodal involvement at the time of diagnosis. Immunohistochemically, all cases displayed B-cell markers and light chain restriction. Tropism of tumour cells for the epithelium was a consistent finding. In two cases involvement of Waldeyer's ring was secondary; in one of them the primary tumour was a gastric low-grade B-cell lymphoma of MALT type and in the other a high-grade B-cell non-Hodgkin's lymphoma of the stomach. These findings indicate that low-grade B-cell lymphomas of MALT type occurring in Waldeyer's ring should be included amongst the tumours of the MALT system. We surmise that in Waldeyer's ring such tumours are derived from the marginal zone, as has already been postulated for similar gastric tumours.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 182 (1963), S. 305-307 
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 6 (1960), S. 243-246 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 213 (1961), S. 606-624 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 334 (1961), S. 399-418 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The presence of alkaline phosphatase was investigated in slide preparations and smears of lymph nodes with the azo dye method. In the case of normal or hyperplastic lymph nodes, capillaries and arterioles are regularly and most strongly positive; the phosphatase activity in the endothelium of the venules, the larger blood vessels and the lymph vessels is irregular. One occasionally finds a few positive fibroblasts in the capsule and trabeculae. In addition, the pulpa sometimes shows a reaction in the region of the sinus, especially of the marginal sinus, and in the region of the germinal centers which appears to be associated with fibers. The activity in the region of the germinal centers is most fully developed with severe follicular lymphatic hyperplasia. A considerable degree of alkaline phosphatase activity can be noted at the edge of tubercles and tubercular caseous foci and in the scarified areas of the lympho-granulomatosis. In lymph node smears, elements interpreted as large reticulum cells were found to be about 16% phosphatase active; in part these cells are for certain vascular endothelium and fibroblasts. In the smears, we also found small lymphoid reticulum cells which gave a clear cut phosphatase reaction. No alkaline phosphatase activity could be demonstrated in the tissue mast cells, at least, that is, in their granula. Phosphatase activity could be clearly demonstrated in slide preparations as in smears in a part of the cells from 2 lymphosarcomas.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 335 (1962), S. 491-512 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The esterase activity of cells of lymph nodes was studied in sections and touch preparations by using α-naphthyl-acetate and naphthol-AS-acetate as substrates. The reaction with α-naphthyl-acetate was always more intense than with naphthol-AS-acetate, except in tissue mast cells. We found the most positive reaction in the phagocytic cells; namely in the sinus endothelial cells, in the reticulum cells of the pulp and follicles (here especially in the cells that phagocytize nuclear debris), and in the epithelioid cells and Langhans giant cells. The plump epithelioid cells reacted much more intensely than the thinner ones. The tissue mast cells, the Hodgkins' cells, and the Sternberg giant cells show edless activity. The regenerating cells of the lymph nodes, the basophilic stem cells and germinoblasts, were esterase negative, as were the lymphocytes and plasma cells. By means of their positive reaction in touch preparations small reticulum cells could be differentiated from the lymphocytes. In addition, some of the middle reticular “Reizzellen” could be classified with the histiocytes. The esterase reaction provided a good method of surveying the number and distribution of functionally active reticulum cells. The cells of monocytic leukemia showed esterase activity enabling them to be differentiated readily from paramyeloblasts. The esterases as demonstrated probably belonged to the generalGomori type, and possibly were ester-splitting peptidases.
    Notes: Zusammenfassung Die Esteraseaktivität der Lymphknotenzellen wurde mit den Substraten α-Naphthylacetat und Naphthol-AS-Acetat im Schnitt- und Tupfpräparat geprüft. Die Reaktion mit α-Naphthylacetat ist stets stärker als diejenige mit Naphthol-AS-Acetat, außer bei den Gewebsmastzellen. Die stärkste positive Reaktion finden wir in den phagocytosefähigen Zellen, nämlich in Sinusretothelien, Reticulumzellen der Pulpa und Follikeln (hier besonders in Kerntrümmerphagen !), Epitheloidzellen und Langhansschen Riesenzellen. Die „saftigen“ Epitheloidzellen reagieren viel stärker als die „dürren“. Eine geringere Aktivität zeigen die Gewebsmastzellen, Hodgkinzellen und Sternbergschen Riesenzellen. Die regenerierenden Zellen des Lymphknotens — basophile Stammzellen und Germinoblasten — sind wie die Lymphocyten und Plasmazellen esterasenegativ. Im Tupfpräparat konnten kleine Reticulumzellen durch ihre positive Reaktion von Lymphocyten abgegrenzt werden. Auch gelang es, einen Teil der „mittleren retikulären Reizzellen“ den Histiocyten zuzuordnen. Für die Diagnostik gestattet die Esterasereaktion einen guten Überblick über Zahl und Verteilung funktionell-aktiver Reticulumzellen im Schnitt- und Tupfpräparat. Ein Teil der Retikulosarkome enthält esterasepositive Zellen. Auch die Zellen der Monocytenleukämie zeigen großenteils Esteraseaktivität, wodurch sie sich leicht von den Paramyeloblasten unterscheiden lassen. Alle übrigen Neubildungen des blutbildenden Gewebes reagieren negativ. Die gefundenen Esterasen zählen wahrscheinlich zum „allgemeinen Typ“Gomoris und sind möglicherweise als esterspaltende Peptidasen anzusprechen.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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