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  • 1
    Electronic Resource
    Electronic Resource
    Atopic dermatitis and congenital deafness (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 99 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a family with perceptive, non-progressive hearing loss several of the members suffered from atopic dermatitis. The proband had a severe atopic dermatitis and an extremely high IgE value. Some of the family members suffered from atopic dermatitis, others from deafness, and some from both diseases. The co-existence of these two disorders has been previously described in two families. Atopic dermatitis and perceptive, non-progressive congenital deafness might be genetically associated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb02004.x
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  • 2
    Electronic Resource
    Electronic Resource
    Allergic contact dermatitis from croton (Codiaeum) (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 3 (1977), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1977.tb03609.x
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  • 3
    Electronic Resource
    Electronic Resource
    Contractile responses to direct stimulation of frog slow muscle fibres before and after denervation (1979)
    Springer
    Pflügers Archiv 382 (1979), S. 43-50 
    Details
    ISSN: 1432-2013
    Keywords: Slow fibres ; Contractile responses ; Effect of denervation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 1. The contractile responses of single slow muscle fibres were investigated under isometric conditions. The fibres were isolated from normal and denervated iliofibularis muscles ofRana temporaria. Direct stimulation was achieved by external application of electrical pulses or depolarizing solutions (40 mM K and acetylcholine 10\t-6 g/ml). 2. Upon electrical stimulation normal slow fibres developed contractions whose amplitude increased steadily with the strength of the pulses. These contractions did not exceed 0.22 kg/cm2, and their rates of rise and fall were approximately 1/6 of those observed in twitch fibres. During pulses of several 100 ms duration the tension continued to rise slowly until the end of the pulses. Application of 40 mM K or acetylcholine resulted in contractures which reached maximum values of 1.71 and 1.87 kg/cm2, respectively, after less than 1 min; little relaxation occurred during the following minutes. 3. The responses of slow fibres denervated for 9−76 days differed in several respects from those of normal slow fibres. a) The contractions elicited by electrical stimulation became faster but their amplitude decreased; the relationship between tension and pulse strength remained, however, essentially unchanged. b) Small and short contractions could be observed during and at the end of stimulating current pulses. Their amplitude was independent of the amplitude and duration of the stimuli; they were blocked by tetrodotoxin and must be attributed to action potentials. c) The ability to develop and maintain tension was reduced. Maximum values of K- and acetylcholine contractures were generally only 50% of those observed in normal slow fibres. Maintenance of tension was markedly reduced in some fibres, less so in others. 4. It is concluded that incorporation of Na channels into its membrane does not transform the slow fibre into a type of fibre which resembles a twitch fibre.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585902
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of nerve length and temperature on the induction of action potentials in denervated slow muscle fibres of the frog (1977)
    Springer
    Pflügers Archiv 372 (1977), S. 17-22 
    Details
    ISSN: 1432-2013
    Keywords: Slow muscle fibres ; Action potential ; Nerve stump ; Temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A. Pyriformis and extensor longus digiti IV muscles of Rana temporaria were denervated by cutting the sciatic or peroneal nerve at various distances from the muscles. Slow fibres were identified by their membrane time constants, and examined for their ability to produce action potentials in response to intracellularly applied current pulses. B. The slow muscle fibres acquired the ability to generate action potentials several days after denervation. The duration of this latent period depended on the length of the peripheral nerve stump, and on the temperature at which the frogs were kept after the operation. C. At 18°C the latent period increased by 0.36 days per mm of sciatic nerve stump. At 11.5° C the corresponding value was 0.7 days/mm. The effect of length of the peroneal nerve was smaller than that of the sciatic nerve. D. It is suggested that the peripheral nerve stump serves as a reservoir of ‘trophic’ material which is transported towards the slow fibres at a rate of 2.8 mm/day (at 18° C) and seems to block the formation of Na channels. TheQ 10 value of this transport system would be 2.7.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582201
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  • 5
    Electronic Resource
    Electronic Resource
    Changes in envelope permeability during chloroplast development (1976)
    Springer
    Planta 129 (1976), S. 69-73 
    Details
    ISSN: 1432-2048
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The permeability of the plastid envelope during the development of Avena sativa plastids was investigated by light scattering and uptake of various labelled compounds (malate, succinate, glutamate, α-ketoglutarate, citrate, glycine, sucrose). The results presented show that a primary event during greening is a change in permeability, thereby allowing an increased transport of metabolites across the membranes of very early etio-chloroplast stages. The results are discussed in view of an adaption of the plastid envelope permeability to the changing requirements of externally synthesized precursors and intermediates during development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390916
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  • 6
    Electronic Resource
    Electronic Resource
    Cardiotone Wirkung einiger Zucker (1964)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 247 (1964), S. 338-339 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02308435
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  • 7
    Electronic Resource
    Electronic Resource
    Untersuchungen über die Verwendbarkeit von Radio-Salyrgan® zur Nierenszintigraphie (1962)
    Springer
    Journal of molecular medicine 40 (1962), S. 1245-1252 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die vorgelegten Untersuchungen zeigen, daß nach intravenöser Applikation von Radio-Salyrgan bei Ratten und Kaninchen eine renale203Hg-Anreicherung bis zu 60% der verabreichten Aktivität eintritt, während bei Mäusen etwa 10% gespeichert werden. Die renale203Hg-Aufnahme erreicht ihr Maximum nach 15–60 min; nach 8 Std sind nur noch 10% der Maximalmenge in den Nieren nachweisbar. Durch Zusatz von Theophyllin wird die203Hg-Aufnahme der Nieren modifiziert, ebenso durch Änderung der Dosis. Außer in den Nieren und im Urin finden sich nennenswerte203Hg-Mengen nur im Magen-Darmkanal sowic kurzzeitig in der Leber. Nach diesen Befunden kann angenommen werden, daß Radio-Salyrgan für die szintigraphische Darstellung des Nierenparenchyms geeignet ist, da bei ausreichender renaler Anreicherung mit einer vertretbaren Strahlenbelastung des Patienten gerechnet werden darf. Erste klinische Prüfungen haben diese Annahme bestätigt. Die notwendigen Salyrgan-Mengen liegen stets unter der therapeutisch wirksamen Dosis, so daß schädliche Nebenwirkungen nicht zu erwarten sind. Darüber hinaus ist das Präparat möglicherweise auch für die Funktionsdiagnostik der Niere verwendbar; diese Frage wird z. Z. klinisch geprüft.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484390
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  • 8
    Electronic Resource
    Electronic Resource
    In vitro-Untersuchungen zur Frage der Fibrinolyse und Thrombolyse durch Streptokinase (1963)
    Springer
    Journal of molecular medicine 41 (1963), S. 1010-1014 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Nur in vitro-Versuche mit Zugabe der Streptokinase nach der Gerinnung („äußere Lyse“) sind mit den therapeutischen Verhältnissen bei der Behandlung thromboembolischer Erkrankungen vergleichbar. In Erweiterung früherer Versuche wurden Nativblut- und Citratplasmagerinnsel in vitro extrem hohen Streptokinasedosen ausgesetzt. Während es an den Citratplasmagerinnseln zu einer völligen Lyse kommt, zeigen die Nativblutgerinnsel keinerlei Auflösung. Unter Luftabschluß gebildete Nativblutgerinnsel zeigten unter Streptokinase weder bei Luftzutritt noch bei Luftabschluß während des Lyseversuches eine Lösung. Unter Luftabschluß gebildete Citratblutgerinnsel zeigten auch im Lyseversuch unter Luftabschluß eine deutliche Verkleinerung. Mit dem Präparat Varidase, das neben Streptokinase auch Streptodornase enthält, kommt es zu den gleichen Versuchsergebnissen wie mit Streptokinase allein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478864
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  • 9
    Electronic Resource
    Electronic Resource
    Untersuchungen über die Verwendbarkeit von Inulin-131J zur Funktionsdiagnostik der Niere (1964)
    Springer
    Journal of molecular medicine 42 (1964), S. 966-967 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Animal tests with Inulin-131I were carried out for the first time for the purpose of developing a radio-medical method for the investigation of the glomerular function of the kidneys. Distribution studies in rats revealed renal accumulation of 12 or 15%, respectively, after the administration of 3 or 30 mg/kg by intravenous injection. After 4 hours the preparation was excreted completely. The time-activity curves measured above the kidneys in rats and dogs showed the peak 2 min after injection (30 mg/kg) or 5 min after injection (3 mg/kg). According to these findings Inulin-131I can be applied clinically as a renal diagnostic. As according to the prevailing opinion, Inulin-131I is particularly suitable for registering the glomerular function, and Hippuran-131J in addition for that of the tubular function, a sensible combination of both tests should allow better and more differentiated results than the present nephrographic methods.
    Notes: Zusammenfassung Mit dem Ziel, ein nuklearmedizinisches Verfahren zur Untersuchung der glomerulären Funktion der Niere zu entwickeln, wurden erstmals Tierversuche mit Inulin-131J durchgeführt. Verteilungsstudien an Ratten ergaben nach i. v. Injektion von 3 bzw. 30 mg/kg eine renale Akkumulation von 12% bzw. 15% der Eingabe. Nach 4 Std war das Präparat vollständig ausgeschieden. Über den Nieren gemessene Zeit-Aktivitätskurven bei Ratten und Hunden zeigten Gipfel 2 min p.i. (30 mg/kg) bzw. 5 min p.i. (3 mg/kg). Nach diesen Befunden kann Inulin-131J für die Nierendiagnostik klinisch eingesetzt werden. Da — nach der gültigen Auffassung — mit Inulin-131J vorwiegend die glomeruläre, mit Hippuran-131J zusätzlich die tubuläre Funktion erfaßt wird, muß die sinnvolle Kombination beider Teste differenziertere und bessere Aussagen als die bisherigen nephrographischen Methoden gestatten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484424
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Zum Mechanismus der Fibrinolyse durch Streptokinase (1963)
    Springer
    Journal of molecular medicine 41 (1963), S. 1200-1203 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Zur Prüfung des Mechanismus der Fibrinolyse werden Gerinnsel aus gleichen Mengen von recalcifiziertem Citratplasma in Röhrchen verschiedener Weite gleichen Streptokinasemengen in physiologischer Kochsalzlösung ausgesetzt. Hierbei ergibt sich, daß die Lysegeschwindigkeit bei gleicher Streptokinasemenge der Berührungsoberfläche des Gerinnsels mit der Streptokinase proportional ist, daß die Lyse von den Gerinnseloberfläche her schichtweise fortschreitet und daß die Gerinnsel nicht von innen nach außen aufgebrochen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01480264
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