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Effect of amobarbital sodium on the flicker-intensity function for the human fovea (1961)

Granger, G. W. ; Ikeda, H.

Springer

Psychopharmacology 2 (1961), S. 258-267

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ISSN: 1432-2072

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Measurements of the foveal critical flicker frequency (c.f.f.) were obtained from six subjects over a wide range of retinal illumination (I) before and after the oral administration of 200 mg amobarbital sodium. Although the drug did not affect the basic shape of the sigmoid function relating c.f.f. to log I the curves of all subjects were displaced downward on the frequency axis to lower critical frequencies. As this effect is analogous to reducing the area of foveal stimulation it was suggested that the drug may cause a functional loss of neural elements either in the retina itself or more centrally. Possible improvements in technique to enable observations to be extended to higher and lower intensities and to other parts of the retina were briefly discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00411194

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