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  • 1960-1964  (8)
  • 1
    Electronic Resource
    Electronic Resource
    Threshold for eliciting the hippocampal theta-rhythm by electrical stimulation in tegmentum and hypothalamus during cortical spreading depression in rats (1962)
    Springer
    Cellular and molecular life sciences 18 (1962), S. 22-24 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Vorübergehende ein- oder beidseitige funktionelle Dekortikation mittels «spreading depression» ergibt bei elektrischer Reizung des Tegmentums oder Hypothalamus einen Schwellenanstieg des Weckeffektes. Die Reaktionsunterschiede der Hirnteile werden über die theta-Aktivität im Hippokampus beurteilt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02136637
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of drugs and neocortical spreading depression on hippocampal ‘arousal reaction’ (1963)
    Springer
    Cellular and molecular life sciences 19 (1963), S. 427-428 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung In leichter Barbiturat- oder Chloralosenarkose wird dieϑ-Aktivität im Hippocampus, durch äussere oder retikulare Stimulierung induziert, von einer desynchronisierten Hippocampus-Aktivität abgelöst. Die Amplitude dieser durch Anästhetika hervorgerufenen langsamen hohen Wellen wird während der neocortikal sich ausbreitenden Depression reversibel verkleinert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02171529
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Leão's spreading depression in the cerebellum of rat (1961)
    Springer
    Cellular and molecular life sciences 17 (1961), S. 572-573 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Ischämie ruft in der Kleinhirnrinde eine ähnliche Depolarisation hervor wie in der Grosshirnrinde. Durch lokale KCl-Applikation erhält man in der Kleinhirnrinde langsame Potentialwellen, die in Amplitude und Ausbreitungsgeschwindigkeit der «spreading depression» vonLeão in der Grosshirnrinde entsprechen. Ischämie und lokale Applikation von 2,4-Dinitrophenol bewirken in beiden Rindengebieten gleiche Verschiebungen der Kaliumionen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02156433
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Acoustic collicular evoked responses during cortical spreading depression in freely moving unanesthetized rats (1962)
    Springer
    Cellular and molecular life sciences 18 (1962), S. 417-418 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Bei Ratten wurde mittels «Spreading Depression» eine funktionelle Dekortikation erzeugt. Habituation und Deshabituation akustischer fortgeleiteter Potentiale (evoked responses) im Colliculus caudalis bleiben erhalten. Auch die reversible Abnahme der «evoked responses» während der Orientierungsreaktion bleibt erhalten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02151495
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Comparative study of sleep cycles in rodents (1964)
    Springer
    Cellular and molecular life sciences 20 (1964), S. 280-281 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Bei Nagetieren (Kaninchen, Ratte, Maus) vergleichbarer Gehirnorganisation sind die Schlafcyclen, die durch regelmässiges Alternieren von (a) generalisierter langsamer unregelmässiger hochvoltiger Aktivität und (b) neokortikaler Desynchronisierung und regelmässiger hippocampaler υ-Aktivität charakterisiert sind, um so schneller, je kleiner die Tiere sind. Dies zeigt, dass der Mechanismus des Alternierens der Schlafphasen von Stoffwechselfaktoren, die im unteren Teil des Hirnstammes liegen, kontrolliert ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02151809
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Physostigmine induced hippocampal theta activity and learning in rats (1962)
    Springer
    Psychopharmacology 3 (1962), S. 254-263 
    Details
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of physostigmine on EEG activity and conditioning was studied in rats. Theta activity develops in the hippocampus of curarized or freely moving unanesthetized animals 3–7 min after i.p. injection of 1 mg/kg physostigmine salicylate, attains maximum after 10 min and disappears after 30–60 min. Gradual impairment of learning corresponds to the development of theta waves. One-trial acquisition of a passive avoidance reaction (avoiding a compartment with electrifiable floor) is completely suppressed 10 min after application of 1.0 or 0.5 mg/kg physostigmine and to a lesser extent even after 0.2 mg/kg physostigmine. No retention of this reaction was found 24 h after onetrial learning when physostigmine (0.5 mg/kg) was applied 8 min before the retention test. On the contrary the same physostigmine dose does not impair the retention of an overtrained (four times) passive avoidance reaction. Also retention of an overlearned active avoidance reaction (running to the safe part of the apparatus is not affected by 0.5 mg/kg physostigmine and only partly impaired by 1 mg/kg physostigmine. The functional significance of the hippocampal theta activity is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411366
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Influence of atropine on sleep cycle in rats (1964)
    Springer
    Psychopharmacology 5 (1964), S. 126-135 
    Details
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In freely moving rats with implanted electrodes the influence of subcutaneously administered atropine sulphate on EEG signs of sleep cycles was analysed. Four subsequent single doses of 0.75; 1.0; 1.25; 2.25 or 3.0 mg/kg of atropine repeated in 30 min intervals were applied, the total doses being 3.0; 4.0; 5.0; 9.0 resp. 12 mg/kg. Even after high doses of atropine sulphate about 40% of the sleep EEG activity is covered by sleep cycles (regular alternation of generalized slow wave activity with neocortical desynchronization combined with hippocampal theta activity) not differing from normal cycles significantly, the rest being a generalized high voltage slow wave irregular activity. After atropine hippocampal theta activity during phase 2 shows, in contradistinction to control records, a spontaneous recruiting like, spindle-like alternation of the amplitude of the waves interrupted by periods of irregular activity. After atropine the arousing effects of reticular stimulation (repeated regularly in 1 min intervals) becomes less pronounced, the incidence of arousal reactions after uniform stimuli being significantly decreased. Nevertheless, the gradual decrease of reticular excitability during the last part of phase 1 of sleep can still be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00413049
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of atropine on learning, extinction, retention and retrieval in rats (1964)
    Springer
    Psychopharmacology 5 (1964), S. 255-263 
    Details
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary EEG changes induced by intraperitoneal injection of 6 mg/kg atropine sulphate were studied in freely moving rats with implanted electrodes. Sleep-like high voltage slow wave activity appeared in neocortex, hippocampus and reticular formation attaining maximum approximately 20 minutes after atropine injection. At the height of the atropine effect one-trial learning of a passive avoidance reaction was partly impaired. So was extinction of this overtrained reaction. Atropine injected 20 minutes before the retention test adversely affected retrieval of threshold conditioned reactions; this effect could not be demonstrated with slightly overtrained behavior. Atropine impaired neither the consolidation nor the storage of memory traces. The atropine induced dissociation between EEG and behavior is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02341258
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    Paper (German National Licenses)
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