ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Thiosemicarbazones of aromatic aldehydes react with acetic anhydride to give well-defined N4,S-diacetyl derivatives, which readily undergo oxidative cyclisation to 2-aryl-4-acetamido-1,3,4-thiadiazoles. From these intermediates, aryl-thiadiazoles - especially 2-(2′-pyridyl)-1,3,4-thiadiazole, inaccessible by the common methods - can be obtained by acidic deacetylation, SANDMEYER substitution and catalytic dehalogenation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19580410714
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