ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The glycosidation of 4-benzyloxy-7-hydroxy-8-methyl-cumarin (2) with 2,3-0-carbonyl-β-noviosyl chloride (1) leading to the α-glycoside (3) is described. This intermediate is transformed successively : (a) by hydrogenolysis (4), (b) introduction of an amine function (5) (6), (c) acylation with 4-acetoxy-3-(isopent-2′-enyl)-benzoyl chloride (10), (d) ammonolysis of 10, into a mixture of novobiocin (11) and isonovo-biocin (12), of which novobiocin was obtained by fractional crystallisation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19640470208
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