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  • 1950-1954  (17)
  • 1
    Electronic Resource
    Electronic Resource
    Advances in the field of adrenal cortical hormones (1954)
    Springer
    Cellular and molecular life sciences 10 (1954), S. 397-416 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Aus den Arbeiten der letzten zwei Jahre auf dem Gebiet der Nebennierenrinden-Hormone stechen — was die Herstellung neuer, hochwirksamer Verbindungen anbetrifft — die Isolierung und Konstitutionsaufklärung des natürlichen Hormons Aldosteron und die synthetische Gewinnung der 9α-halogenierten Hydrocortisone hervor. Diese Ergebnisse haben den Weg zu weiteren wesentlichen Entwicklungen eines Gebietes geöffnet, das mit Cortison und Hydrocortison abgeschlossen schien. Auf dem Gebiete der Teilsynthese wurde die Herstellung von 11-oxygenierten aus 12-oxygenierten Derivaten und insbesondere aus Verbindungen ohne Sauerstoff im Ring C stark ausgebaut. Bei der letzteren liegen die wichtigsten Befunde wohl in den mikrobiologischen Hydroxylierungen in 11-Stellung und den anschliessenden chemischen Umwandlungen. Erst kürzlich ist es möglich geworden, auch die typischen Seitenketten durch mikrobiologische Methoden zu gewinnen. Die Totalsynthese der Hormone aus einfachsten chemischen Bausteinen wurde entwickelt und macht rasche Forschritte. Die Auffassungen über die Biosynthese haben konkretere Formen angenommen. Die unzähligen Arbeiten über Katabolismus und klinische Verwendung der Nebennierenrinden-Hormone konnten im Rahmen dieser Übersicht nicht einmal gestreift werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02318502
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Isolation of crystalline aldosterone from the urine of a nephrotic patient (1954)
    Springer
    Cellular and molecular life sciences 10 (1954), S. 456-458 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Es ist erstmals gelungen, Aldosteron aus menschlichem Urin zu isolieren. Eine Fraktion des 13-Tage-Harnes von einem Knaben mit Nephrose und massiven Ödemen ergab 1,0 mg dieses biologisch hochaktiven Hormons in kristallisierter Form. Da der Gesamtgehalt gegen 3 mg betrug, stellt solcher Harn ein geeignetes Ausgangsmaterial dar zur extraktiven Gewinnung von Aldosteron. Letzteres erwies sich in seinen Eigenschaften als identisch mit Aldosteron aus Rinder-Nebennieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02170397
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  • 3
    Electronic Resource
    Electronic Resource
    Konstitution des Aldosterons, des neuen Mineralocorticoids (1954)
    Springer
    Cellular and molecular life sciences 10 (1954), S. 132-133 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chemical degradation of the new crystalline mineralocorticoid provisionally called electrocortin has shown that this compound is 11β, 21-dihydroxy-3, 20-diketo-4-pregnen-18-al. In solution this reacts mainly as the 11-hemiacetal. We suggest aldosterone as a definitive name for the compound.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02158515
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  • 4
    Electronic Resource
    Electronic Resource
    Biologische Hydroxylierungen von Steroiden (1952)
    Springer
    Cellular and molecular life sciences 8 (1952), S. 422-424 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary New observations on the necessary cofactors for the hydroxylation of steroids using adrenal homogenates are described. By microbiological hydroxylation of steroids preferably in 11α-position using molds i. a. the new 11-epimers of corticosterone and 17-hydroxy-corticosterone have been obtained. They are lacking high mineralocorticoidal activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02296685
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  • 5
    Electronic Resource
    Electronic Resource
    Isolierung eines neuen kristallisierten Hormons aus Nebennieren mit besonders hoher Wirksamkeit auf den Mineralstoffwechsel (1953)
    Springer
    Cellular and molecular life sciences 9 (1953), S. 333-335 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new crystalline compound has been isolated from beef adrenal extracts. In three different assay methods using epinephrectomised rats or dogs it was found to be from 30 to 100 times as potent as cortexone (11-deoxy-corticosterone) or its acetate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02155834
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  • 6
    Electronic Resource
    Electronic Resource
    Mikrobiologische Reaktionen (1953)
    Springer
    Cellular and molecular life sciences 9 (1953), S. 371-372 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Certain fungi, especially of the genusFusarium, are capable of rapidly degrading the side chain of 20-keto-pregnenes to the corresponding 17-ketones and, simultaneously, of dehydrogenating ringA. ThusΔ 1,4-3,17-diketo-androstadiene is formed almost quantitatively fromΔ 4-3,20-diketo-pregnenes and fromΔ 4-3,17-diketo-androstene, and in lower yields from the analogousΔ 5-3β-hydroxy compounds. The side chain of saturated 3-keto- or 3β-hydroxy-allopregnane-20-ones is also degraded quickly, but dehydrogenation in ringA proceeds more slowly. 17α-hydroxy-groups prevent the degradation of the side chain. By means of this microbiological process in combination withInhoffen's aromatisation reaction, progesterone can be transformed in only two steps into estrone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02167636
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  • 7
    Electronic Resource
    Electronic Resource
    Über Steroide. 110. Mitteilung. Herstellung von 7;9,11-Dienen der Androstan-Reihe (1952)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 35 (1952), S. 284-294 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Starting from Δ5-3β, 17β-diacetoxy-androstene (I) the new Δ7;9,11-3β, 17β-dihydroxy-androstadiene (XX) and the corresponding diacetate have been synthesized. These compounds are useful in the preparation of steroids with oxygen in 11-position.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19520350137
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  • 8
    Electronic Resource
    Electronic Resource
    Über Steroide. 109. Mitteilung. Papierchromatographie von schwach polaren Steroiden (1952)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 35 (1952), S. 276-283 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A critical survey of the known methods of paper chromatography of steroids is given. A new solvent system is described which, in connection with several colour reactions, is particularly applicable to the separation, identification and purity analysis of weakly polar steroids or corresponding esters and ethers. The stationary phase is formed by ethyleneglycol monophenylether (phenylcellosolve) on Whatman paper No. 7, the mobile phase by heptane or a similar non-polar solvent.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19520350136
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  • 9
    Electronic Resource
    Electronic Resource
    Über Steroide. 116. Mitteilung. Abbau der Gallensäuren-Seitenkette XIII. Eine vereinfachte Darstellung von Δ20,22;23-21-Brom-choladienen (1953)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 36 (1953), S. 891-895 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: By treating a Δ23-24, 24-diphenyl-cholene with 2 moles of N-bromo-succinimide in allylbromide the corresponding Δ20,22;23-21-bromo-24, 24-diphenyl-choladiene is obtained directly in a 70% yield. Thus three of the usual reactions in the side chain degradation of bile acids to adrenal cortical hormones are concentrated into one, experimentally very simple step. Some conversions connected with this reaction are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19530360420
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  • 10
    Electronic Resource
    Electronic Resource
    Über Steroide. 118. Mitteilung. Ein neues Verfahren zur Herstellung von Steroiden mit 11β-Hydroxylgruppe. I. Versuche an Verbindungen der Spirostanreihe (1953)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 36 (1953), S. 1241-1251 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A simple five-step conversion of 12-ketosteroids into 11 β-hydroxy compounds (and also 11-ketones) through 11 β, 12 β-epoxides is described. The process can be accomplished with high yields, as it is shown in the present paper dealing with the application to hecogenin acetate.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19530360604
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