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  • 1
    Electronic Resource
    Electronic Resource
    Five new experimental stations at the SRS Daresbury from a 6 T superconducting wiggler magnet : Proceedings of the 5th international conference on synchrotron radiation instrumentation (1995)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 1633-1635 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Daresbury Laboratory is currently completing the construction and commissioning of five new experimental research stations utilizing high flux hard x-ray radiation from a 6 T superconducting wiggler magnet. The broad areas of science covered by the new stations and the novel features are presented. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1145867
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  • 2
    Electronic Resource
    Electronic Resource
    Test of an 18-m-long suspended modecleaner cavity (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 2443-2448 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Fluctuations in laser beam geometry such as lateral beam movement and beam width variation can produce perturbations in the output signal of a laser interferometer through various coupling mechanisms. In order to avoid this type of laser noise from degrading the sensitivity of interferometers designed to detect gravitational radiation, currently planned long-base-line detectors will employ resonant optical filters called modecleaners to suppress beam geometry noise. Here we describe a prototype modecleaner cavity constructed at Glasgow having an optical path length of 18 m and containing four suspended mirrors. We present results detailing various aspects of its performance. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1147194
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis, Structure and Properties of Five-Coordinate Copper(II) Complexes of Pentadentate Ligands with Pyridyl Pendant Arms (1995)
    s.l. : American Chemical Society
    Inorganic chemistry 34 (1995), S. 254-261 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00105a041
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  • 4
    Electronic Resource
    Electronic Resource
    Barbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications (1998)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 105 (1998), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine whether prophylactic, low dose controlled-release aspirin improves outcome for pregnant women and their babies in Barbados.Design Randomised placebo-controlled trial.Setting The Queen Elizabeth Hospital, Barbados.Population All women attending antenatal clinics between 12 and 32 weeks of gestation were eligible, if without specific contraindications to aspirin and unlikely to deliver immediately.Methods Randomisation was computer-generated in the antenatal clinic; 1822 women were allocated to receive 75 mg controlled-release aspirin and 1825 matching placebo.Main outcome measures Proteinuric pre-eclampsia, other pregnancy-induced hypertension, pregnancy duration, birthweight, stillbirths and neonatal deaths, major neonatal events.Results All but three women from each group were followed up successfully. Forty-four percent were primigravid, and 8% had previous obstetric complications. There were no significant differences between the allocated treatment groups in the incidence of proteinuric pre-eclampsia (40 [2.2%] of those allocated aspirin, compared with 46 [2.5%] allocated placebo), of preterm delivery (255 [14.0%] vs 270 [14.8%]), of birthweight 〈 1500 g (32 [1.7%] vs 33 [1.8%]) or of stillbirth and neonatal death (44 [2.4%] vs 38 [2.1%]). Aspirin was not associated with excess risk of maternal orfetal bleeding.Conclusions The results of this study in Barbados do not support the routine use of low dose aspirin for prevention of pre-eclampsia or its complications, confirming results of previous large trials in other settings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1998.tb10088.x
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  • 5
    Electronic Resource
    Electronic Resource
    A pragmatic randomised comparison of transcervical resection of the endometrium with endometrial laser ablation for the treatment of menorrhagia (1997)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 104 (1997), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To compare endometrial laser ablation (ELA) with transcervical resection of the endometrium (TCRE) in the treatment of menorrhagia.Design Randomised controlled trial.Setting Gynaecology department of a large teaching hospital.Participants Women with menorrhagia due to dysfunctional uterine bleeding (n= 372) were randomly allocated to ELA (n= 188) or TCRE (n= 184).Main outcome measures Operative complications, post-operative recovery, relief of menstrual and other symptoms, need for further surgical treatment, satisfaction with treatment after 6 and 12 months, and differential resource use.Results TCRE was significantly quicker, with lower rates of fluid overload. Perioperative morbidity was low and similar hi both groups. Outcome at 12 months was also similar: 72 women (45%) had either amenorrhoea or brown discharge in the ELA group compared with 71 (49%) in the TCRE group; 79 (49%) versus 68 (46%) had lighter periods. Thirty (16%) versus36 (20%) had received further surgical treatment: 9 (5%) compared with 25 (14%) had had a hysterectomy, and 21 (11%) versus 11 (6%) had received repeat ablation. Anxiety and depression, dysmenorrhoea and pre-menstrual symptoms were improved by both procedures and bladder symptoms were affected by neither. At 12 months 148 (90%) women in the ELA group and 140 (91%) women in the TCRE group were satisfied with their treatment. The estimated additional cost of ELA was £145 per procedure.Conclusions At one year there was no clear difference in clinical outcome between ELA and TCRE.Both procedures were associated with low morbidity. ELA was the more costly procedure. Despite the need for further surgery for about one in six women, satisfaction rates were high following both ELA and TCRE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1997.tb11540.x
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  • 6
    Electronic Resource
    Electronic Resource
    Authors' Reply (1999)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 106 (1999), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1999.tb08164.x
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  • 7
    Electronic Resource
    Electronic Resource
    Synthetic chemical diversity: solid phase synthesis of libraries of C2 symmetric inhibitors of HIV protease containing diamino diol and diamino alcohol cores (1995)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 38 (1995), S. 2995-3002 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00016a001
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  • 8
    Electronic Resource
    Electronic Resource
    The effect of reagent translational energy on the dynamics of the reaction O(3P)+CS(X 1Σ+)→CO(X 1Σ+)+S(3P) (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 106 (1997), S. 1391-1401 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Two different regimes of collision energy are used to explore the role of additional translational energy on the dynamics of the reaction O(3P)+CS(X 1Σ+)→CO(X 1Σ+)+S(3P). Product CO rotational quantum-state population distributions for CO(v′=12, 13, and 14) are used as an indicator of the reaction dynamics, and these rotational distributions are presented for reaction of thermal reagents (at 298 K) and for translationally hot oxygen atoms formed by the 355 nm photolysis of NO2. The experimental measurements are compared with the results of quasiclassical trajectory calculations performed on an empirical London–Eyring–Polanyi–Sato potential energy surface tailored to model the observed dynamics for thermal reagents. Efficient conversion of the extra translational energy into product rotation is seen for all vibrational levels studied. The data are found to fit a simple model in which the fraction of the extra kinetic energy which appears as product rotation varies linearly with kinetic energy, and becomes unity for the fastest oxygen atoms produced by photolysis. The experimental results are interpreted in terms of an increasingly bent transition state for the reaction at higher collision energies, with the possibility of reagent reorientation towards a more linear transition state as the kinetic energy is decreased. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.474097
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  • 9
    Electronic Resource
    Electronic Resource
    ELECTROPHYSIOLOGICAL PROPERTIES OF THE RAT MIDDLE CEREBRAL ARTERY AT DIFFERENT LEVELS OF PASSIVE WALL TENSION (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Simultaneous measurements of intracellular membrane potential and myogenic tone of proximal segments of the rat middle cerebral artery, mounted in a small vessel myograph, were made at two levels of passive wall tension.2. At low levels of passive tension (less than 0.25mN/mm) vessels had a resting membrane potential of approximately -65mV. Addition of KCl (5–60 mmol/L), BaCl2 (0.01–3 mmol/L) or tetraethylammonium (TEA; 0.1–3 mmol/L) resulted in a concentration-dependent depolarization, to approximately—40 mV, generally associated with a contractile response. After the application of high levels of passive tension (to approximately 2mN/mm maximum) the resting membrane potential of the smooth muscle cells was—40 to—45 mV. This more positive membrane potential was generally associated with an increase in myogenic tone of the vessel. Under these conditions, addition of 5–20 mmol/L KCl resulted in a strong hyperpolarization of the cell along with a concomitant decrease in myogenic tone of the artery. The hyperpolarization and vasorelaxation induced by KCl (5–20 mmol/L) were blocked by BaCl2 (0.5–1 mmol/L).3. While the addition of ryanodine (10 μmol/L) to vessels under low tension had no effect, when added to a vessel under high tension, this agent caused a rhythmic oscillation in membrane potential. This oscillation was augmented by BaCl2 (1mmol/L) and inhibited by nifedipine (10nmol/L) and 4-aminopyridine (1 mmol/L).4. This study suggests that the electrophysiological and mechanical properties of the isolated rat middle cerebral artery depend on the passive resting conditions under which the vessel is studied. The depolarization of membrane potential observed with increased passive tension appears to result from the closure of an inward rectifying K+ channel. These results indicate that the inward rectifying K+ channel plays an important role in regulating vascular reactivity due to its functional dependence on the mechanical status of the blood vessel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb01926.x
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  • 10
    Electronic Resource
    Electronic Resource
    KATP CHANNEL BLOCKING ACTIONS OF QUATERNARY IONS PLAY NO ROLE IN THEIR ANTIPROLIFERATIVE ACTION ON MOUSE LEUKAEMIA AND RAT VASCULAR SMOOTH MUSCLE CELLS IN VITRO (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 25 (1998), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The aim of the present study was to investigate the possibility that, in the two cell lines examined, alterations in cell growth caused by lipophilic quaternary ions may involve KATP channels. We examined the effect of tetraphenylphosphonium (TPP), tetraphenylboron (TPB), rhodamine 123, dequalinium chloride (DECA) and the non-quaternary ion cisplatin on the proliferation of L1210 mouse leukaemia cells and rat smooth muscle cells in vitro. The KATP channel opener levcromakalim (LKM) and the Katp channel antagonist glibenclamide were also tested.2. From growth-inhibition studies, the rank order of potency (based on pIC50 values) using L1210 leukaemia cells was: DECA (6.61) 〉 cisplatin (6.09) = rhodamine 123 (6.01) 〉 TPP (5.61) 〉 TPB (4.25). Levcromakalim and glibenclamide were found to be inactive at the maximum concentrations used (100 μmol/L). A different rank order of potency was obtained in rat aortic smooth muscle cells: cisplatin (6.33) 〉 DECA (5.67) 〉 TPP (4.96) 〉 rhodamine 123 (4.1). Tetraphenylboron (30μmol/L), LKM (100 μmol/L) and glibenclamide (100 μmol/L) were found to be inactive.3. When the negatively charged TPB (30 μmol/L) was combined with some of the active agents, the potency of the active agents was increased. Thus, in L1210 cells, rhodamine 123, DECA and TPP were all more potent at inhibiting cell growth in the presence of TPB. Tetraphenylboron had no effect on cisplatin in this cell line. In rat smooth muscle cells, TPB (30 μ mol/L) potentiated the effect of rhodamine 123 but had no effect on the actions of cisplatin, DECA or TPP.4. In functional studies, rhodamine 123 was a weak antagonist of the vasorelaxant responses to the KATP channel opener LKM in the porcine right circumflex artery in vitro. The pKB value obtained for rhodamine 123 at 100 μmol/L was 4.95. Dequalinium chloride was inactive.5. We found no correlation between the actions of the compounds tested to antagonize KATP channels and their ability to inhibit cell proliferation. In addition, compounds known to regulate KATP channel activity failed to influence proliferative rates. These results suggest that KATP channels are not involved in the antiproliferative action of TPP and other quaternary ions in the two cell lines studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1998.tb02172.x
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