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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 32 (1910), S. 1628-1636 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    The @Muslim world 4 (1914), S. 0 
    ISSN: 1478-1913
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Theology and Religious Studies
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing
    Clinical and experimental dermatology 28 (2003), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Human immunodeficiency virus (HIV) infects and destroys crucial components of the immune system, leaving patients susceptible to a number of viral, bacterial and fungal diseases. Viral warts are caused by human papillomavirus infection and are a common skin disease that afflicts HIV-infected patients. Treatment modalities currently rely on destruction of the infected tissue or interruption of cell division; however, frequent recurrence is a particular challenge in HIV-infected patients. We report the case of a 41-year-old HIV-positive man with multiple common warts located on his hands and feet. Following 5 months of treatment with imiquimod, an immune response modifier, as a 5% cream, complete clearance of all warts was achieved. Mild erythma, itching and burning at the application site was observed in the early stages of treatment. The patient showed no relapse of warts at the 30-month follow-up visit.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background  Matrix metalloproteinases (MMPs) contribute to matrix remodelling in venous leg ulcers. Extracellular MMP inducer (EMMPRIN; CD147) has been reported to increase MMP expression, and membrane type 1 MMP (MT1-MMP) has been implicated in the activation of MMPs. Objectives  To examine whether and to what degree EMMPRIN, MMP-2, MT1-MMP and membrane type 2 MMP (MT2-MMP) are expressed in venous leg ulcers as well as the association with MMP activity. Methods  EMMPRIN, MMP-2, MT1-MMP and MT2-MMP were analysed by zymography and immunohistochemistry in biopsies from healthy skin and lesional tissue from venous leg ulcers. Results  Zymography provided direct evidence of increased proteolytic activity of MMP-2 in lesional skin in comparison with healthy controls. Immunostaining showed intense expression of EMMPRIN, MMP-2, MT1-MMP and MT2-MMP in dermal structures of venous leg ulcers, whereas only EMMPRIN and MMP-2 showed elevated expression in perivascular regions. Our findings indicate that venous leg ulcers are characterized by elevated expression of EMMPRIN, MMP-2, MT1-MMP and MT2-MMP. The immunohistological findings of skin alterations reflect the dynamic process of activation of soluble and membrane-bound MMPs, which may be highly induced by EMMPRIN. Conclusions  These data suggest for the first time that membrane-bound MMPs may favour enhanced turnover of the extracellular matrix and support unrestrained MMP activity in venous leg ulcers.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Der Schmerz 14 (2000), S. 77-83 
    ISSN: 1432-2129
    Keywords: Schlüsselwörter Fibromyalgiesyndrom ; Versorgungssituation ; Inanspruchnahme ; Patientenzufriedenheit ; Keywords Fibromyalgia syndrome ; Health care utilization ; Treatment satisfaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background: The purpose of the study was to examine the pain related health care utilization in patients with fibromyalgia syndrome. Methods: In a multicenter study six rheumatological hospitals associated in the rheumatological center of Heidelberg participated. All consecutive patients which fulfilled the ACR-criteria of fibromyalgia were assessed. Data about pain and related treatments were available from n=259 patients. Results: Patients suffered from chronic generalized pain on average for 5 years before being diagnosed as fibromyalgia. In most of the cases longlasting localized pain symptoms preceeded generalized pain. The spectrum of pain related treatments seems to be wide and arbitrary: 87% took questionable or excessive medication. 86% had some form of physiotherapy and 41% already experienced psychological treatment. 28% of the patients consulted dental surgeons including teeth extraction and 20% underwent multiple orthopaedic surgery. A mean of five different health care professionals were consulted regarding the pain problem. Treatment statisfaction rated by the patients was lowest with pharmacological and highest with psychological treatment and physiotherapy. Conclusions: The health care-seeking behavior of fibromyalgia-patients seems to be characterized by a multitude of different treatment attempts. Treatment was often invasive and focused on localized symptoms rather than on the generalized pain syndrome. An early confirmation of the diagnosis and a more evidence based treatment is strongly indicated.
    Notes: Zusammenfassung Fragestellung: Ziel der vorliegenden Studie ist die Analyse der Inanspruchnahme medizinischer Versorgungsleistungen von Fibromyalgiepatienten. Methode: Im Rahmen einer multizentrischen Erhebung in 6 Kliniken des Rheumazentrums Heidelberg wurden alle Patienten mit Fibromyalgiesyndrom (gemäß ACR 1990) hinsichtlich ihrer bisherigen Behandlungen befragt. Es liegen Daten von insgesamt n=259 Patienten vor. Ergebnisse: Im Durchschnitt hatten die Patienten bereits 5,4 Jahre vor der Diagnosestellung chronisch generalisierte Schmerzen (Diagnoselatenz). Dem Stadium der Schmerzgeneralisierung ging dabei ein über 10-jähriges Stadium lokalisierter Schmerzen voraus. Zahlreiche therapeutische Maßnahmen gegen die Schmerzsymptomatik wurden durchgeführt: 87% nahmen Medikamente – häufig eine fragwürdige Polymedikation. 86% erhielten aktive oder passive Physiotherapie und 41% wurden psychologisch behandelt. Bei 28% der Patienten wurde wegen der Schmerzen eine Zahnbehandlung durchgeführt. 20% wurden z. T. mehrfach orthopädisch operiert, nach der Schmerzgeneralisierung sogar signifikant mehr als vorher. Insgesamt wurden im Schnitt von den Patienten Ärzte in 5 verschiedenen Fachrichtungen konsultiert. Die Patienten selber beurteilten die medikamentöse Behandlung als am wenigsten hilfreich und passive Physiotherapie neben psychologischen Interventionen als am effektivsten. Schlussfolgerungen: Die Versorgungssituation der Patienten besteht aus einer Vielzahl unterschiedlicher Behandlungsversuche, welche jedoch eher auf lokalisierte Probleme als auf die generalisierte Schmerzsymptomatik abzielen. Eine frühzeitige Diagnosestellung und ein evidenzbasiertes Behandlungskonzept erscheinen dringend erforderlich.
    Type of Medium: Electronic Resource
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  • 6
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    Berlin : Periodicals Archive Online (PAO)
    Orientalistische Literaturzeitung. 14 (1911) 294 
    ISSN: 0030-5383
    Topics: Linguistics and Literary Studies , Ethnic Sciences , History
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  • 7
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    Berlin : Periodicals Archive Online (PAO)
    Orientalistische Literaturzeitung. 14 (1911) 465 
    ISSN: 0030-5383
    Topics: Linguistics and Literary Studies , Ethnic Sciences , History
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  • 8
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    Berlin : Periodicals Archive Online (PAO)
    Orientalistische Literaturzeitung. 14 (1911) 129 
    ISSN: 0030-5383
    Topics: Linguistics and Literary Studies , Ethnic Sciences , History
    Notes: Besprechungen
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  • 9
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    Berlin : Periodicals Archive Online (PAO)
    Orientalistische Literaturzeitung. 14 (1911) 365 
    ISSN: 0030-5383
    Topics: Linguistics and Literary Studies , Ethnic Sciences , History
    Notes: Besprechungen
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  • 10
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    Berlin : Periodicals Archive Online (PAO)
    Orientalistische Literaturzeitung. 14 (1911) 281 
    ISSN: 0030-5383
    Topics: Linguistics and Literary Studies , Ethnic Sciences , History
    Notes: Sprechsaal
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