ISSN:
0947-3440
Keywords:
Alkaloids
;
Enantiospecific synthesis
;
Chiral building blocks
;
2,5-Disubstituted piperidines
;
(+)-Pseudoconhydrine
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A novel methodology for the synthesis of any one of the four stereoisomers of a 2,5-disubstituted piperidine in optically pure form is described, starting from readily available chiral building blocks 10 and 11 (or their antipodes). The utility of this approach is demonstrated in the total synthesis of (+)-pseudoconhydrine hydrochloride, the structure of which was confirmed by X-ray analysis.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199719970633
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