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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 343 (1991), S. 225-227 
    ISSN: 1432-1912
    Keywords: Histamine H3 receptors ; Gastric acid secretion ; Conscious gastric fistula cat ; (R)α-methylhistamine ; Thioperamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an attempt to assess the role of histamine H3 receptors in the control of gastric acid secretion, the effects of the selective histamine H3 receptor agonist, (R)α-methylhistamine and antagonist, thioperamide were evaluated in the conscious gastric fistula cat under basal conditions and against different stimuli. (R)α-methylhistamine (0.05–0.2 μmol/kg/h) was ineffective against spontaneous and dimaprit-induced acid secretion; it also did not reduce significantly pentagastr-ininduced acid output, but caused a dose-dependent (0.05–0.1 μmol/kg/h) and significant inhibition of the acid response to 2-deoxy-d-glucose. Thioperamide (0.02–0.04 μmol/kg/h) did not modify spontaneous acid secretion, whereas it evoked a significant enhancement of the acid response to submaximal doses (50 mg/kg i. v.) of 2-deoxy-d-glucose. Thioperamide completely reversed the inhibitory effect of (R)α-methylhistamine against 2-deoxy-d-glucose-induced secretion, while leaving unaffected the inhibition induced by somatostatin. These data suggest that histamine H3 receptors may be involved in the control of acid secretion stimulated by indirectly acting secretagogues.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 22 (1976), S. 953-956 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 23 (1977), S. 948-951 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A class of dynamic model approximation techniques based on a frequency domain Taylor series expansion is presented. These methods yield low-order models and are analytical rather than computational in nature; that is, one can retain important parameters (which may be time varying) from the original model in functional form in the low-order model. This feature is very attractive for on-line updating of the simplified model and subsequent control of the process. An example for a tenth-order original model has shown that the analytical low-order models provide excellent approximations to the step response of the original system.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 22 (1976), S. 894-904 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A new tracer technique is reported for the determination of liquid-solid contacting efficiency and liquid holdup in trickle beds packed with small alumina particles. Holdup was a function of liquid mass velocity for both porous and nonporous packing. Contacting efficiency remained uniform at a level of 65%.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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