ISSN:
0887-624X
Keywords:
(heparin-PEO) grafted segmented polyurethaneurea
;
surface modification
;
nonthrombogenic surface
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A new synthetic approach for the preparation of segmented polyurethaneurea (SPUU)-PEO-Heparin graft copolymers (B-PEO-Hep) has been developed. The procedure involved the coupling of hexamethylene diisocyanate (HMDI) to soluble Biomer® (B) through an allophanate/biuret reaction. The free isocyanate (NCO) groups attached to Biomer® were then coupled to PEO terminal hydroxyl groups to form PEO grafted Biomer® (B-PEO). B-PEO free hydroxy groups were modified with HMDI to introduce terminal isocyanate groups. The NCO functionalized B-PEO was then coupled to heparin (Hep) functional groups (—OH, —NH2) producing B-PEO-Hep graft copolymer. Synthetic intermediates were confirmed by FTIR, NCO group determination, and toluidine blue heparin assay. Physical characterization techniques, such as contact angle measurements, water swelling, light scattering measurements, and DSC thermal analysis, detailed properties of the graft copolymer containing covalently bound heparin. This new heparinized copolymer can be applied as a coating on other existing blood contacting surfaces without changing bulk properties. The heparin bioactivity observed attests to the usefulness of this new procedure as a coating to improve the blood compatibility of blood-contacting surfaces.
Additional Material:
13 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/pola.1991.080291206
Permalink
