ISSN:
1434-4475
Keywords:
1,2-Amino-alcohols
;
Enantiomerically pure
;
erythro-Configuration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The synthesis of both enantiomers of norephedrine and norisoephedrine is described to present a method for the preparation of enantiomerically pure branched 1,2-aminoalcohols. In a one pot reaction enantiomerically pure cyanohydrins bearing an acetal protective group are subjected to Grignard-reaction followed by addition of lithium aluminum hydride. After deprotection the target compounds are obtained.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00810829
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