ISSN:
1435-1536
Keywords:
Sequentialpolydepsipeptide
;
polymericmicrosphere
;
poly(L-alanyl-L-alanyl-γ-ethyl L-glutamyl-L-lactyl)
;
solventevaporationprocess
;
drugdeliverysystem
;
malerat
;
ratprostate
;
17Β estradiol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Abstract A sequential polydepsipeptide containing a tripeptide sequence L-alanyl-Lalanylγ-ethyl L-glutamyl and anα-hydroxy acid L-lactic acid, poly(Ala-Ala-Glu(OEt)-Lac), was synthesized to prepare the microspherical particles by the solvent evaporation process. In this case, the solvents play the most important role for the preparation of polydepsipeptide microspheres and, as an example, when 200 mg of the polydepsipeptide dissolved in 10 ml of 98/2% chloroform/dichloroacetic acid mixture was stirred at 400 rpm and 30
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01411103
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