ISSN:
1432-2072
Keywords:
Key words Nicotine
;
Ibogaine
;
18-Methoxycoronaridine
;
In vivo microdialysis
;
Drug self-administration
;
Smoking
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Two studies were conducted to assess, in vivo, potential anti-nicotinic effects of the iboga alkaloid ibogaine and its synthetic congener 18-methoxycoronaridine (18-MC). As previously demonstrated for ibogaine, using microdialysis, pretreatment (19 h beforehand) with 18-MC (40 mg/kg, IP) significantly attenuated nicotine-induced dopamine release in the nucleus accumbens of awake and freely moving rats. In an oral model of nicotine self-administration, both ibogaine and 18-MC decreased rats’ preferences for nicotine for at least 24 h. Acutely, during the first hour after administration, ibogaine depressed responding for water as well as for nicotine; however, during this same time, 18-MC reduced nicotine intake without affecting responding for water. The results suggest that 18-MC might be the prototype of a new treatment for smoking.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002130050716
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