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  • Selective white matter lesion  (2)
  • 1H NMR  (1)
  • After-potential  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Multiple actions of substance P and other tachykinins on sympathetic neurons in rat prevertebral ganglia
    Amsterdam : Elsevier
    Regulatory Peptides 46 (1993), S. 257-259 
    Details
    ISSN: 0167-0115
    Schlagwort(e): After-potential ; Autonomic nervous system ; Polymerase chain reaction (PCR) ; Substance P ; Sympathetic ganglion ; Tachykinin ; Tachykinin receptor
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(93)90052-A
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Comparative study on pathogenesis of selective cerebral lesions in carbon monoxide poisoning and nitrogen hypoxia in cats (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 265-272 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Carbon monoxide encephalopathy ; Nitrogen hypoxia ; Selective white matter lesion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Since in a previous study hypoxia and subsequent hypotension were considered to be essential for the pathogenesis of carbon monoxide encephalopathy (CO-encephalopathy), experiments were conducted to see whether a combination of nitrogen hypoxia and subsequent systemic hypotension of similar degree and duration as in the previous experimental CO poisoning could induce the same lesion in the CNS of cats. The partial pressure of blood oxygen was reduced to less than 26 mm Hg by increasing the concentration of nitrogen in N2/O2 gas to be inhaled in 1.5 h and then the aortic blood pressure (BP) was reduced to 60–80 mm Hg by blood depletion and ganglion-blockage for 1 h. In 11 of the 15 cats, lesions were produced in the CNS which were similar by light and electron microscopy to those in CO-encephalopathy. In control groups which were treated by hypoxemia only, hypotension only or a combination of CO2-gas inhalation and hypotension without hypoxemia, such lesions were not found in the cerebral white matter. Considering the pathogenesis of lesions in the cerebral white matter in both nitrogen hypoxia and CO-poisoning, two factors, i.e., hypoxemia and subsequent systemic hypotension, are common and essential. Further, the enormous vasodilation in the cerebral white matter induced by hypoxemia and subsequent drop in BP seem to cause a more severe circulatory disturbance in the cerebral white matter than in the cortex.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00691257
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  • 3
    Digitale Medien
    Digitale Medien
    A study of experimental cyanide encephalopathy in the acute phase —Physiological and neuropathological correlation (1984)
    Springer
    Acta neuropathologica 64 (1984), S. 99-107 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Cyanide encephalopathy ; Selective white matter lesion ; Cerebral local blood flow
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A study was performed to elucidate the significance of various physiological factors contributing to the pathogenesis of experimental cyanide encephalopathy, such as the systemic arterial blood pressure, venous pressure, common carotid blood flow and local blood flow of the cerebral grey and white matters, and blood gas including pH. The histology and topography of the brain damage was also analysed. Twenty-one cats were divided into four groups. The animals in groups 1, 2 and 3 were subjected to continuous infusion of 0.2% sodium cyanide solution and to the ensuing hypotension below 100 mm Hg by administering a ganglion-blocking drug and by respiratory arrest. Severe damage developed in the deep cerebral white matter, corpus callosum, pallidum and substantia nigra, but the damage of the cerebral cortex and hippocampus was not remarkable. The animals in group 4 that were subjected to cyanide infusion without significant hypotension (above 100 mm Hg), but to the same degree of acidosis as that of the the other groups, had similar morphological changes, but to a lesser degree. On the basis of our physiological and morphological findings, we speculated that the pathophysiological factors of tissue hypoxia and subsequent hypotension operated in cyanide leucoencephalopathy. The topographic selectivity seemed to be related to the characteristic cerebral vascular system, and the severity of the white matter lesions was related to the intensity of both hypoxia and hypotension during cyanide infusion, but not to the extent of acidosis, total dose of cyanide or duration of its infusion per se.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00695572
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  • 4
    Digitale Medien
    Digitale Medien
    Effect of intramolecular and intermolecular exchange processes on the 1H NMR spectra of 2-chloro-1,3,2-dioxarsolanes (1987)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 25 (1987), S. 484-488 
    Details
    ISSN: 0749-1581
    Schlagwort(e): 1H NMR ; 13C NMR ; 2-Chloro-1,3,2-dioxarsolanes ; Intra- and inter-molecular exchange ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The 1H and 13C NMR spectra of solutions of 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxarsolane (1) and 2-chloro-1,3,2-dioxarsolane (2) are reported as a function of temperature, concentration and solvent. These data indicate rapid intramolecular conformational averaging for (1) and (2) under all the conditions investigated. Additionally, intermolecular conformational averaging processes are shown to be present. The kinetic parameters for intermolecular exchange were obtained from line shape analysis of the 1H NMR data. These results indicate the intermolecular exchange to be bimolecular in nature, involving a four-centered transition state. The O—CH2—CH2-O torsional angle of (2) has been calculated from the analysis of its AA′BB′ 1H NMR spectral patterns, obtained at low concentrations in the absence of intermolecular exchange.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrc.1260250605
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