ISSN:
0935-6304
Keywords:
Capillary gas chromatography
;
Two-phase acylation
;
Aziridine
;
2-Chloroethylamine
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The determination of small, water soluble amines such as aziridine and 2-chloroethylamine, in drug substances at trace levels is described. After removal of the bulk of the drug substance by extraction or precipitation, derivatization with acid chlorides is performed. In a two-phase (water-organic solvent) system, this derivatization reaction is accomplished almost simultaneously with the extraction of the product to the organic layer. The organic layer is analyzed by gas chromatography using on-column injection and selective detection. Detection limits are approx. 0.2 mg/kg for aziridine and approx. 0.5 mg/kg for 2-chloroethylamine.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240120906
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