ISSN:
1573-7284
Keywords:
Leptospires
;
Antibody persistence
;
West Indies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Participants in a survey for leptospiral agglutinating antibodies undertaken in Trinidad, West Indies, in 1977–78, were further monitored for up to 5-and-a-half years. 52 individuals with a titre ≥ 1:400 were matched for age, sex and occupation with seronegative subjects. They were re-bled twice (on average 2.38 and 4.84 years later), and changes of titre were noted. At the first follow-up, 78% of negative controls remained negative, and 22%, showed titre changes. Among the seropositive subjects, 47% showed a fall in titre, 38% showed no change, and in 15% the titre rose. New exposure rates between the original and first follow-up samples were 96/1,000 survey population per year in the controls, and 68/1,000 for the subjects with titres 〉 1:400. Between the first and second followup, 47% of the seropositive subjects lost titre, 40% showed no change, and 13% showed a rise in titre. These data demonstrate that although antibody titres may be maintained for a few years at the same level, or show a loss as is usually expected, about 8.3% of individuals in Trinidad may be infected/reinfected per year. The infection/reinfection rate is an important factor in the epidemiology of leptospirosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00155547
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