ISSN:
1432-2072
Keywords:
Cannabis
;
catecholamines
;
Hyperreactivity
;
Hyperthermia
;
Pimozide
;
Atropine
;
6-OHDA
;
Stereotypy
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The behavioral responses of the rat to an extract of Cannabis sativa were examined after IP injection of 5, 15 and 30 mg/kg (expressed as Δ 9 tetrahydrocannabinol). The lowest dose of the extract induced stereotyped behavior (rhythmic head movements, intermittent gnawing and sniffing) together with hypersensitivity to stimuli and hyperthermia. The administration of higher doses of the extract resulted, initially, in similar behavioral effects but of greater intensity, followed by a cataleptic state alternating with atonic muscular prostration; rectal temperature was decreased. Pre-treatment with 6-hydroxydopamine (6-OHDA, which produces degeneration of catecholamine-containing nerve terminals) or pimozide (blocker of dopamine receptors) significantly reduced both stereotypy and hyperreactivity. Thermic effects were also antagonized by 6-OHDA pre-treatment. Cannabis-induced catalepsy was enhanced by pimozide but reduced by atropine (3 mg/kg SC). These results support the hypothesis that catecholamines play an important role in the complex behavioral effects of cannabis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00432176
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