ISSN:
0749-1581
Keywords:
Antiparasitic antibiotic
;
Double-quantum NMR
;
2D13C NMR
;
1H NMR
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
LL-F28249-α is a potent antiparasitic antibiotic produced by Streptomyces cyaneogriseus ssp. noncyanogenus. Its complete 13C NMR spectral assignment based on two-dimensional double-quantum experiments in a sample at natural isotopic abundance is described. The proton NMR assignments were made from a combination of homonuclear and heteronuclear two-dimensional correlation experiments. Proton-proton scalar couplings, nuclear Over-hauser enhancements and molecular mechanics energy minimization calculations are also reported, permitting a comparison of solution conformation with the known x-ray structure adapted from a closely related analogue.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260270504
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