ISSN:
0749-1581
Keywords:
NMR
;
13C CP/MAS
;
1H Solid-state rearrangement
;
3-Amino-1-and -2-(chloroacetyl)pyrazole
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Reaction of 3-aminopyrazole (1) with chloroacetyl chloride gives a mixture of 3-amino-1- and -2-(chloroacetyl)pyrazole (2 and 3), both of which rearrange in the solid-state to 3-(chloroacetamido)pyrazole (4) over a period of a few days. The course of the rearrangements was monitored directly by CP/MAS NMR and indirectly by 1H NMR spectroscopy; the results suggest that the mechanism involves 3 → 2 → 4.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260320412
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