ISSN:
1572-879X
Keywords:
piperidine
;
formaldehyde
;
3-alkylpyridine
;
selective synthesis
;
mechanism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The reaction of piperidine with formaldehyde over γ-alumina, Na+-γ-alumina, NiAl2O4 and CuAl2O4 was studied as a model system in order to understand the mechanism and selectivity of alkylpyridine formation from piperidine and carbonyl compounds. Along with the expected 3-picoline, 2-picoline and other products were also formed. The selectivity for 3-picoline was high on γ-alumina whereas on NiAl2O4, 2-picoline was selectively formed. The formation of the different products has been rationalized and a probable mechanism for the formation of 2-picoline has been presented.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00806899
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