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  • 36.10.Gv  (2)
  • Key words Dedifferentiated chondrosarcoma  (1)
  • 1
    ISSN: 1432-2307
    Keywords: Key words Dedifferentiated chondrosarcoma ; p53 mutation ; p53 LOH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We investigated a dedifferentiated chondrosarcoma of a 61-year-old woman with an osteosarcomatous high-grade component for p53 alteration. The low-grade cartilaginous and the high-grade osteosarcomatous components of the tumor were macrodissected and evaluated separately by immunohistochemistry and molecular biology. We used PCR-SSCP analysis and direct sequencing to screen exons 4–8 for p53 mutations. The p53 intron 1-polymorphism was investigated for loss of heterozygosity. A functionally relevant p53 missense mutation in codon 193 of exon 6 (A-to-T transversion) with loss of wild-type allele was detected only in the dedifferentiated component. Using the monoclonal antibody DO-1, immunohistochemistry failed to show p53 overexpression. This evidence of p53 mutation may be regarded as at least a co-factor that ”switched” the preexisting low-grade conventional chondrosarcoma to a highly malignant dedifferentiated tumor.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 341 (1991), S. 101-105 
    ISSN: 1434-601X
    Keywords: 36.10.Gv
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Absolute pionic x-ray intensities have been measured for Mg and Fe. The accuracy achieved was 2% of the line intensity for the most prominent transitions. In the Balmer series of Mg and the Paschen series of Fe the crossover transitions were found to be even more attenuated than the transitions between circular states, as deduced, for example, by comparison with muonic atoms; no crossover transitions were observed in the Fe Balmer series. According to cascade calculations based on the experimental intensities more than half of the pions are absorbed in Fe already from levels with principal quantum numbern〉17 by strong interaction.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 346 (1993), S. 81-84 
    ISSN: 1434-601X
    Keywords: 36.10.Gv
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The spectral flux densityn(T) of μ− emerging from a Au or MgF2 moderator has been measured at low energiesT using time-of-flight. Fromn(T) the stopping powerS(T) of Au was determined for 2 keV≤T≤22 keV, and of MgF2 for 2 keV≤T≤12 keV. For Au,S(T) is smaller than calculated values obtained from proton atomic data practically in the wholeT range (Barkas effect); at lowT S(T) approaches the calculated values. For MgF2,S(T) agrees fairly with the calculated values above 5 keV and then drops below these values. We ascribe this dropping to the large energy gap of the MgF2 insulator.
    Type of Medium: Electronic Resource
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