ISSN:
1573-7217
Keywords:
amifostine
;
autologous bone marrow transplantation (ABMT)
;
breast cancer
;
4-hydroperoxycyclophoshamide (4-HC)
;
marrow purging
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary High-dose chemotherapy and autologous bone marrow transplantation (ABMT) are commonly used to treat selected patients with high-risk breast cancer. A limitation of ABMT is that clonogenic cancer cells could be collected with the bone marrow and produce a relapse of disease when reinfused into patients. Purging the marrowex vivo may eliminate the tumor cells, but it can also delay engraftment. We employed two different purging methods whereby breast cancer cells were depleted without delaying engraftment. The addition of WR-2721 (amifostine) to 4-hydroperoxycyclophosphamide (4-HC) reduced the time to engraftment by 10 days compared with marrow purged with 4-HC alone (26 versus 37 days, respectively). The positive selection of CD34+ hematopoietic progenitors produced engraftment within 21 days. The use of granulocyte colony-stimulating factor (G-CSF) accelerated the engraftment time of CD34+ hematopoietic progenitors to 11 days.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00668356
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