ISSN:
1432-0584
Keywords:
Autologous bone marrow transplantation
;
Acute leukemia
;
4-hydroperoxycyclophosphamide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary An autologous bone marrow transplantation (ABMT) was performed in a 45-year-old male patient with AML in therapy-resistant first relapse including CNS-disease. The marrow graft was harvested 18 months before, at the beginning of first remission, and was subjected to an in-vitro incubation with 4-hydroperoxycyclophosphamide (4-HC) prior to cryopreservation to eliminate residual clonogenic tumor cells. After myeloablative therapy with high-dose Cyclophosphamide (CY), total body irradiation (TBI) and intrathecal application of Methotrexate (MTX), the manipulated marrow graft was reinfused. The myelopoietic reconstitution started already 6 days after ABMT and was completed 40 days thereafter. There is evidence for a complete remission in marrow and spinal fluid observed over a period of 4 months.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00320664
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