ISSN:
1432-1335
Keywords:
Yoshida sarcoma
;
Glandular stomach
;
5-Fluorouracil, methyl-CCNU, mitomycin C, adriamycin, cytosine arabinoside
;
Two-drug combinations
;
Sprague-Dawley rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The chemotherapeutic activity of five cytostatic drugs was investigated experimentally in monotherapy and in two-drug combinations, using Yoshida sarcoma cells implanted into the wall of the glandular stomach of Sprague-Dawley rats. In monotherapy, the antibiotic agent mitomycin C and the nitrosourea methyl-CCNU exhibited the highest cytotoxic activity in this tumor model. In combination therapy, the combination of these two drugs was superior to all the other therapeutic schemes tested. In general, the results demonstrate a marked superiority of combination therapy in comparison with monotherapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00395753
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