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Buspirone does not produce a 5-HT1A-mediated decrease in temperature in man (1991)

Lee, H. S. ; Meltzer, H. Y.

Springer

Journal of neural transmission 86 (1991), S. 71-76

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ISSN: 1435-1463

Keywords: Buspirone ; 5-HT1A receptor ; DA2 receptor ; body temperature

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Buspirone, a putative serotonin (5-HT)1A partial agonist, did not produce hypothermia in 17 normal volunteers in a placebo controlled, single blind study. Thus, buspirone may be a weaker agonist at those 5-HT1A receptors which mediate hypothermia compared to ipsapirone or gepirone, two other 5-HT1A partial agonists which have been reported to produce hypothermia by a 5-HT1A-mediated mechanism.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01250377

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