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  • 10  (1)
  • 5-Hydroxytryptamine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 315 (1981), S. 195-201 
    ISSN: 1432-1912
    Keywords: Clonidine ; 5-Hydroxytryptamine ; Hypothermia ; Metabolic rate ; Cutaneous vasodilatation ; Respiration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The thermoregulatory outputs (including metabolic, respiratory and vasomotor activities) produced by an injection of clonidine or 5-hydroxytryptamine (5-HT) into the third cerebral ventricle of conscious rabbits were assessed at three different ambient temperatures (T a) of 2, 22 and 32°C. 2. When injected into the third cerebral ventricle, both clonidine and 5-HT produced a dose-dependent hypothermia in rabbits at both 2 and 22°C T a. The hypothermia was due to a decrease in metabolic heat production (M) at 2°C T a, while at 22°C T a the hypothermia was due to cutaneous vasodilatation. There were no changes in respiratory evaporative heat loss. 3. Furthermore, the clonidine-induced hypothermia was greatly reduced by pretreatment of the animals with either 5,6-dihydroxytryptamine (impairment of central 5-HT pathways) or yohimbine (alpha-adrenergic blocking agent), but not by 6-hydroxydopamine (impairment of central catecholamine pathways). 4. The results indicate that clonidine may act on the α-adrenergic receptors located on central 5-HT pathways to produce a hypothermic action by promoting a decrease in heat production or an increase in heat loss in the rabbit.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 10 (1976), S. 1-13 
    ISSN: 1432-0630
    Keywords: 84 ; 42 ; 10
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract In this paper we present an overview of the spectral domain approach for solving a variety of high frequency diffraction problems. We demonstrate via a number of examples that the fields derived from the use of the Spectral Theory of Diffraction (STD) remain uniformly valid for all observation angles, including the shadow boundary, the reflection boundary and the caustic direction where the conventional Geometrical Theory of Diffraction (GTD) breaks down. Furthermore, we show how the accuracy of STD can be improved and its range extended by combining it with integral equation methods in the spectral domain.
    Type of Medium: Electronic Resource
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