ISSN:
1432-2072
Keywords:
Prostaglandins
;
6-Hydroxydopamine
;
Circling behavior
;
Dopamine
;
Amphetamine
;
Striatum
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effect of prostaglandins (PG) on amphetamine(AMPH)-induced circling was examined in mice unilaterally lesioned with 6-hydroxy-dopamine. At doses of 0.03–1.0 nmol/g, intraventricularly injected PGD2, PGE2, and PGF2α all inhibited AMP-induced circling, while thromboxane-B2 (TxB2) was inactive at 1.0 nmol/g. The inhibition of circling was not due to alterations in body temperature as measured by rectal temperature changes. When injected intrastriatally, the same major PG inhibited AMP-induced circling at the lower doses of 0.01–0.1 nmol/g, while the PGE2 metabolite 13,14-dihydro-15-keto-PGE2 was inactive at 0.1 nmol/g. PG administered alone did not procude circling. For both routes of administration, the order of potency was PGE2〉PGD2〉PGF2α. These results suggest that PG can alter motor function governed by central dopaminergic pathways.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00433733
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