ISSN:
1432-1912
Keywords:
Spontaneosly hypertensive rats
;
Urinary kallikrein
;
Sympathetic activity
;
6-Hydroxydopamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Urinary kallikrein excretion was studied in young, stroke-prone, spontaneously hypertensive rats (spSHR). Seven-week-old spSHR were found to excrete more kallikrein into the urine than normotensive Wistar Kyoto control rats (WKR). “Chemical sympathectomy”, induced by 6-hydroxydopamine (6-OHDA) immediately after birth, resulted in normotensive blood-pressure levels and in a reduction of kallikrein in spSHR. In normotensive WKR, blood pressure and urinary kallikrein excretion were only slightly diminished by 6-OHDA. The results suggest a relationship between sympathetic activity and kallikrein excretion, being especially pronounced in spSHR, which have an elevated sympathetic activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00498573
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