ISSN:
1435-1463
Keywords:
Pain sensitivity
;
substantia nigra
;
corpus striatum
;
dopamine
;
apomorphine
;
haloperidol
;
6-hydroxydopamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In the rat, elevating dopamine content in corpus striatum with electrical stimulation of substantia nigra or direct administration of apomorphine (50–200μg) into the lateral cerebral ventricle or apomorphine (2–10μg) into the caudate-putamen complex decreased pain sensitivity (as shown by an increase in the latency to hind-paw lick in the hot plate test). Furthermore, the decreased pain sensitivity after the central administration of apomorphine was antagonized by pretreatment with haloperidol (a dopamine antagonist). On the other hand, lowering dopamine content in corpus striatum with electrolytic destruction of substantia nigra and 6-hydroxydopamine lesions to the substantia nigra, as well as direct injection of haloperidol into the lateral cerebral ventricle or caudate-putamen complex increased pain sensitivity. The data indicate that activation of striatal dopamine receptors in rat brain induces pain inhibition.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01248953
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