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  • 6-hydroxydopamine  (1)
  • 1
    ISSN: 1432-0878
    Keywords: Vasomotor nerves ; Skeletal muscle ; 6-hydroxydopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Vasomotor nervous distribution to arteries in the cat gastrocnemius and soleus muscles was investigated in the normal and 6-hydroxydopamine treated animal. Muscle samples were processed for the demonstration of acetylcholinesterase by a thiocholine method and for the presence of catecholamines by a formol fluorescence technique. In isolated perfused muscle preparations noradrenaline or adrenaline increased perfusion pressure while acetylcholine or isoprenaline decreased this pressure. A beaded fluorescent periarterial plexus (not visualised after reserpine treatment) was observed. Vasomotor axons, all of which were ACHE-negative, exhibited degenerative changes following 6-hydroxydopamine injection, while ACHE-positive axons outside the adventitial sheath were unaffected. No indication of cholinergic periarterial nerves was found and our evidence suggests that the vasomotor innervation is adrenergic sympathetic in nature.
    Type of Medium: Electronic Resource
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