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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 16 (1988), S. 351-355 
    ISSN: 1434-0879
    Keywords: Intravesical BCG ; Peripheral blood mononuclear cells ; Killer activity against natural killer cell (NK) resistant tumors, NK type precursor and effector cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the mechanism of Bacillus de Calmette Guérin (BCG) bladder instillation therapy, the killer cell activity induced in peripheral blood mononuclear cells (PBMNCs) after BCG instillation was examined. Significant cytotoxic activity against natural killer (NK) cell resistant target tumor cells was detected after 3 days of instillation. To characterize this BCG induced cytotoxic activity further, human PBMNCs were cultured with BCG in vitro. From 24 h maximum cytotoxicity was obtained and continued for 3 days, then decreased slightly. Neither a DNA synthesis inhibitor Cytosine-arabinoside (Ara-C) nor a cytotoxic T cell (CTL) generation inhibitor Cyclosporine A inhibited this killer cell activation. Monoclonal antibody treatment revealed that both precursor and effector cells are Leu1-, 3a-, 7+, 11b+. The recognition specificity from cold target competition experiments was selective. Taken together NK type precursor was activated with BCG into NK type effector which has wider spectrum of target cells than usual NK cell.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-6079
    Keywords: 68.35.Bs ; 71.25.Cx ; 73.20.Dx
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Two dimensional band structure is calculated for a triangular lattice of C60 molecules by using a mixed-basis approach in which wave functions are expanded with not only plane waves but also 1s and 2p atomic orbitals of carbon atoms. The present analysis modeling a charge transfer from Si dimers of the Si (100) surface suggests the existence of a small Fermi-surface. The resulting partial charge distribution is consistent with the recent STM observation of specific stripes, the direction of which is parallel to that of the topmost double bond of C60, regardless of the intermolecular interaction. It is concluded that the orientation of C60 on the Si surface is mainly determined by the direction of dimer arrays and not by the interaction between C60 molecules.
    Type of Medium: Electronic Resource
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