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  • 1
    ISSN: 1432-2072
    Keywords: Key words Alcohol ; Ethanol ; Saccharin ; Self-administration ; Serotonin ; 5-HT1A receptor ; 5-HT2A receptor ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Both 5-HT1A and 5-HT2A receptors have been implicated in modulating ethanol self-administration. A novel serotonergic compound, FG 5974, with combined 5-HT1A agonist/5-HT2A antagonist activities, has shown effects in decreasing ethanol consumption in two-bottle choice paradigms. In the present study, the effect of this compound on operant responding for ethanol (as well as water and a saccharin solution) was compared to compounds possessing the separate neuropharmacological effects of this drug (the 5-HT1A agonist, 8- OH-DPAT, and the 5-HT2A antagonist, amperozide). While all three serotonergic compounds decreased operant responding for ethanol, only FG 5974 had no effect on water and saccharin responding. These results suggest that combined 5HT1A agonist/5-HT2A antagonist activity provides a more selective effect on ethanol reinforcement than either neuropharmacological action alone. Therefore, further analysis of mixed serotonergic compounds in general, and FG 5974 in particular, is warranted as they offer potential treatments for alcoholism.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of elasticity 30 (1993), S. 1-54 
    ISSN: 1573-2681
    Keywords: elastic beam theory ; subcentre invariant manifolds ; dynamical systems ; 73C02 ; 73C10 ; 35A35 ; 58G40
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The subcentre invariant manifold of elasticity in a thin rod may be used to give a rigorous and appealing approach to deriving one-dimensional beam theories. Here I investigate the analytically simple case of the deformations of a perfectly uniform circular rod. Many, traditionally separate, conventional approximations are derived from within this one approach. Furthermore, I show that beam theories are convergent, at least for the circular rod, and obtain an accurate estimate of the limit of their validity. The approximate evolution equations derived by this invariant manifold approach are complete with appropriate initial conditions, forcing and, in at least one case, boundary conditions.
    Type of Medium: Electronic Resource
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