ISSN:
1434-4475
Keywords:
Reissert compounds
;
Intramolecular cyclization
;
8-Methylisoquino[2,1-b][2,7]naphthyridinium chlorides
;
(±)-Alamaridine
;
(±)-epi-Alamaridine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A novel synthesis of 8-methylisoquino[2,1-b][2,7]naphthyridinium salts7 is reported using the intramolecular cyclization of the 1-substituted isoquinolines5 as the key step, which in turn are obtained by alkylation of theReissert compounds1. The salts7 can be reduced by NaBH4 yielding the 8α- and 8β-methylstereomers (±)-alamaridine and (±)-epi-alamaridine9c and11c, respectively.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00811089
Permalink