ISSN:
1432-2072
Keywords:
Drug discrimination test
;
5-HT1A autoreceptor
;
8-OH-DPAT
;
pCPA
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The role of 5-HT1A autoreceptors in the discriminative stimulus properties of 8-OH-DPAT (0.1 mg/kg, SC) in rats, was investigated. Drug lever appropriate responding to 8-OH-DPAT (0.1 mg/kg, SC) and ipsapirone (3 mg/kg, SC) was measured before and after treatment with para-chlorophenylalanine (pCPA) at a dose (150 mg/kg IP, −3 and −2 days) which causes severe depletion of brain 5-HT stores. The recognition of the drug stimulus was not significantly altered by pCPA. These results indicate that activation of 5-HT1A autoreceptors is of minimal importance to the 8-OH-DPAT cue.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02253715
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