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  • 99mTc-ECD  (1)
  • Prunus cerasus  (1)
  • 1
    ISSN: 1432-2072
    Schlagwort(e): Key words SPECT ; Alzheimer’s disease ; Linopirdine ; 99mTc-ECD
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Centrally acting cholinergic drugs have been reported to increase regional cerebral blood flow (rCBF) as measured by single photon emission computed tomography (SPECT) in brain regions affected by Alzheimer’s disease (AD). We studied the effects of the acetylcholine releaser linopirdine (LPD) on SPECT rCBF in patients with probable AD. Twenty-four AD patients (12 M, 12 F; mean age ± SD = 68.9 ±8.2 years) and 13 healthy controls (8 M, 5 F; 68.4 ± 8.0 years) participated. AD patients were scanned with 20 mCi of Tc-99m-ECD at baseline and following 4 weeks of treatment with LPD 40 mg TID (n = 15) or placebo TID (n = 9) in a double-blind trial. Healthy subjects were scanned for comparison with baseline AD scans. Cortical/cerebellar rCBF ratios were derived for nine cortical structures. The combined parietal association cortex showed a 20.6% reduction in patients relative to controls. Patients treated with LPD showed an increase in parietal rCBF of 4.1 ± 5.8%; whereas those treated with placebo showed a decrease of −2.0 ± 7.4% (F = 5.13; df = 1, 22; P = 0.03). These data support the conclusion that rCBF abnormalities in AD are, in part, truly “functional” and can be selectively altered with pharmacological interventions. The parietal activation seen with LPD and other cholinergic AD drug therapies suggests the importance of measuring parietal lobe neuropsychological function in the course of evaluating these drugs.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Euphytica 52 (1991), S. 47-55 
    ISSN: 1573-5060
    Schlagwort(e): Prunus cerasus ; sour cherry ; morphology ; germplasm collection ; genebank ; variation ; principal component analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Summary Morphological traits of 28 full-sib sour cherry (Prunus cerasus L.) families developed with pollen from European sour cherry selections were evaluated with principal component (PC) analysis. The traits which loaded on the first PC were size characters such as lateral length, leaf area, fruit weight, and trunk diameter increase. These character loading on the first PC could be interpreted as representing gradations between morphologies characteristic of the 2 presumed progenitor species, sweet cherry (P. avium L.) and ground cherry (P. fruticosa Pall.). Mean family differences in trunk diameter increase, lateral length, leaf area, and fruit weight varied approximately 12, 3.7, 2.5, and 2 fold, respectively. These results suggest that it may be possible to select sour cherry hybrids approaching the tree and fruit size of either progenitor species. The results are discussed in reference to germplasm collection and the potential of certain cultivars and hybrids as parents.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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