ISSN:
1432-2013
Keywords:
electrogenic Na pump
;
A-V node cell
;
Na injection
;
short-circuiting effect
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Electrogenicity of the Na pump was confirmed by injecting Na salts into a small cluster of A-V node cells. Injection of Na glutamate or Na acetate induced marked hyperpolarization, accompanying with cessation of spontaneous activity. The hyperpolarization exceeded EK in 27 mM K Tyrode solution and was inhibited by 10−5 M strophanthidin. Injection of NaCl or NaI depolarized the membrane. These data showed that inward-going current carried by the injected anion antagonized the outward-going pump current and thus determined the net effect of the injection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00584587
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