ISSN:
1432-2072
Keywords:
Senile organic brain syndrome
;
ACTH 4-10
;
Polypeptide
;
Organon
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Eighteen male and female volunteers over the age of sixty who exhibited mild senile organic brain syndrome were administered ACTH 4-10 (Org OI 63) (30 mg, s.c.) or saline in a 2×2 Latin square design. Subjects experienced a reduction in depression and confusion and an increase in vigor. This evidence of an increase in vigor was supported behaviorally by a delay in the onset of increased latency in reaction time. Data also indicated that retrieval from memory may be enhanced by this compound. The electroencephalogram evinced a shift to lower frequencies under ACTH 4-10, but this effect was primarily noted in the females who received drug followed by placebo. These effects of ACTH 4-10 are intriguing and suggest that further work in this area should be encouraged.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00426731
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