ISSN:
1476-5535
Keywords:
Methionine effect
;
ACV accumulation
;
β-Lactam production
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary Methionine markedly stimulates the biosynthesis of penicillin N and cephalosporin C inCephalosporium acremonium. Examination of intra- and extracellular ACV tripeptide in non-producing mutant N-2 showed that growth in the presence of methionine increased ACV accumulation. Direct measurement of ACV synthetase activity in a cell-free system indicated that the methionine effect was mainly due to induction of this first enzyme of the β-lactam biosynthetic pathway, resulting in a corresponding increase in β-lactam production in both a low-producing strain and a high-producing mutant.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01569547
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