ISSN:
1432-0584
Keywords:
AKR Leukemia
;
Vincristine
;
Recruitment
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined autoradiographic-Feulgen-microspectrophotometric technique. Twelve hours after a single drug injection the stathmokinetic effect of VCR was observed as reflected by an accumulation of cells in the S/G2-M phase of the mitotic cycle. Within 28 h this effect was no longer evident, but the significant increase in % unlabeled S/G2-M cells strongly suggested an influx of previously non-proliferating cells into the proliferating compartment (recruitment).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00320497
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