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  • Henoch-Schönlein purpura  (2)
  • Abtrenn. von Calcium  (1)
  • 1
    ISSN: 1432-198X
    Keywords: IgA nephropathy ; Henoch-Schönlein purpura ; Plasma ; PGI2-like activity ; Lipoproteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma factors influencing vascular PGI2-like activity (PSA) were studied in 45 patients with IgA nephropathy, 18 with Henoch-Schönlein purpura, including 8 children with nephrotic syndrome, and 41 controls. The results were compared with the levels of plasma high-density lipoprotein (HDL), low-density lipoprotein (LDL) and fatty acid components of plasma phospholipids. The plasma of 38 of 45 patients with IgA nephropathy and 14 with Henoch-Schönlein purpura showed a diminished ability or no ability to support PSA. Twenty-three patients with IgA nephropathy and 10 with Henoch-Schönlein purpura exhibited an inhibitory activity against PGI2 production. The plasma HDL level was lower, while the LDL level and the LDL/HDL ratio were significantly higher in IgA nephropathy and Henoch-Schönlein purpura cases than in the controls. A high LDL/HDL ratio was associated with a low plasma PSA. The levels of arachidonic acid and its precursor were not lower in the plasma of patients than in the controls. The decreased PGI2 synthesis may play an important role in the pathogenesis of IgA nephropathy and Henoch-Schönlein purpura, but it can not be explained by reduced PG precursors. LDL may have an inhibitory, and HDL a protective effect on PGI2 synthesis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-198X
    Keywords: Atopy ; IgA nephropathy ; Henoch-Schönlein purpura ; IgE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The incidences of clinical and biological markers of atopy were investigated in 16 children with IgA nephropathy (IgAN) (group A) and in 22 with Henoch-Schönlein purpura nephritis (HSPN) (group B). The incidence of increased plasma IgE levels according to age-matched normal values was significantly higher in group B (17/22, 77%) than in group A (7/16, 44%) (P〈0.05). Although not significant, the incidences of positive RAST tests and of a history of typical atopic symptoms were also higher in group B [10/22 (45%) and 11/22 (50%), respectively] than in group A [4/16 (25%) and 5/16 (31%), respectively]. Moreover, IgE deposits were demonstrated by a peroxidase/anti-peroxidase method on cutaneous Langerhans and mast cells in 4 of 6 patients with HSPN. Thus immunoallergy might account, in some cases, for the cutaneous, intestinal and pulmonary signs observed in HSPN, but not in IgAN. We postulate stimulation of IgE-sensitized mast cells by specific antigens in the presence of IgA circulating immune complexes (CIC), release of vasoactive substances, increased capillary permeability and perivascular deposition of IgA CIC.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 272 (1974), S. 22-24 
    ISSN: 1618-2650
    Keywords: Abtrenn. von Calcium ; Chromatographie, Gel ; Sephadex, Biogel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary The behaviour of calcium ions in calcium chloro-complex form on Biogel P 2 and Sephadex G 15 columns has been investigated at different temperatures. The data suggested that the interaction is an absorptive process. Total separation of calcium ions from organic substances has been achieved by means of gel chromatography carried out at a changed temperature after a partial separation had been made.
    Notes: Zusammenfassung Das Verhalten von Calciumionen in Form des Calcium-chlorokomplexes wurde an Biogel P 2 und Sephadex G 15 bei verschiedenen Temperaturen untersucht. Aus den Ergebnissen ließ sich auf einen Absorptionsprozeß schließen. Eine Trennung der Calciumionen von organischen Substanzen konnte durch Gel-Chromatographie bei veränderter Temperatur nach teilweiser Vortrennung erreicht werden.
    Type of Medium: Electronic Resource
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