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Structure of a monoclinic polymorph of N-[4-(acetyloxy)-phenyl]acetamide, a prodrug of acetaminophen (1999)

Caira, M. R. ; de Wet, F. N. ; Gerber, J. J.

Springer

Journal of chemical crystallography 29 (1999), S. 175-178

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ISSN: 1572-8854

Keywords: Acetaminophen prodrug ; drug polymorphism ; x-ray analysis

Source: Springer Online Journal Archives 1860-2000

Topics: Geosciences , Physics

Notes: Abstract The preparation, single crystal x-ray structure and the computed powder XRD pattern of a monoclinic polymorph of N-[4-(acetyloxy)phenyl]acetamide, a prodrug of acetaminophen, are reported. The polymorph crystallizes in the space group P21/n with Z = 4 and unit cell dimensions a = 7.219(2), b = 8.015(2), c = 16.575(2) Å, β = 92.07(1)°, and V = 958.4(4) Å3. Infinite spiral molecular arrays result from intermolecular head-to-tail hydrogen bonding between the amidic H atom of one molecule and the acetoxy carbonyl oxygen atom of a 21-related molecule.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1009565926282

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