ISSN:
1432-0738
Keywords:
Motor activity
;
Toxicological screening
;
Acetanilide
;
Phenylmercuric acetate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A new method for continuous in-cage monitoring of the activity of rats using passive sensors to detect the animals' infrared emissions, and its usefulness for toxicological screening tests is described. In order to obtain baseline values for toxicological tests, the differences between day and night activity, adaptation to changing day/night rhythm, the effects of handling the animals (measurement of body weight, food and water consumption) and the effect on activity patterns of the female estrus cycle were investigated. In two separate experiments, single doses of acetanilide and phenylmercuric acetate were administered. Passive infrared monitoring of motor activity proved to be a sensitive and discriminating method suitable for quantitative and qualitative assessment of acute toxic effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00316429
Permalink
