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  • 1
    Electronic Resource
    Electronic Resource
    The effect of l-tryptophan on motor activity and its prevention by an extracerebral decarboxylase inhibitor and by 5-HT receptor blockers (1980)
    Springer
    Psychopharmacology 69 (1980), S. 173-177 
    Details
    ISSN: 1432-2072
    Keywords: R04-4602 ; 5-HT Antagonists ; Activity ; Tryptophan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract l-Tryptophan at moderately low dosage (20 mg/kg) reduced the activity of rats taken during a dark period (red light) and put into an open field illuminated by bright white light. Activity was not altered when the field was illuminated by red light. Tryptophan did not cause significant hypoactivity in rats pretreated with the 5-hydroxytryptamine (5-HT) receptor antagonists methysergide, cyproheptadine and metergoline. However, tryptophan did not alter brain 5-HT concentration and only increased 5-hydroxyindoleacetic acid (5-HIAA) slightly in rats killed shortly after behavioural observation. A further indication that the behavioural effect of tryptophan was not due to increased brain 5-HT was its prevention by R04-4602 at a dose sufficient to block peripheral but not central l-aromatic amino acid decarboxylase. The results suggest that the above behavioural effect of l-tryptophan is peripherally mediated. A number of potential mechanism are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427645
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Involvement of dopamine in the antinociceptive response to footshock (1984)
    Springer
    Psychopharmacology 82 (1984), S. 185-188 
    Details
    ISSN: 1432-2072
    Keywords: Stress ; Antinociception ; Dopamine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of drugs which alter dopaminergic function on footshock-induced antinociception were studied in the rat. Antinociception due to brief (30 s) footshock was inversely related to dopamine (DA). Thus, it was increased by the DA receptor antagonists pimozide and haloperidol and decreased by the specific D2 dopamine receptor agonist LY 141865, but not by the specific D1 agonist SKF 38393. Although pimozide increased the antinociceptive effect of 30-s shock, it decreased that of 30-min shock. It is suggested that DA may have physiological roles in stress-induced antinociception, and that these may differ according to the duration of stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427770
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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