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  • 1985-1989  (2)
  • Acute myeloid leukaemia  (1)
  • Myelodysplastic syndromes  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Myeloperoxidase-deficient polymorphonuclear leucocytes. Longitudinal study during the preremission — and the remission phase in acute myeloid leukaemia (1986)
    Springer
    Annals of hematology 52 (1986), S. 237-242 
    Details
    ISSN: 1432-0584
    Keywords: Acute myeloid leukaemia ; Granulocyte myeloperoxidase ; Neutrophil alkaline phosphatase-relapse-remission
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serial determinations of MPO and NAP activities in granulocytes were performed during the preremission phase and the remission phase in patients with AML. Of 18 patients examined during the preremission period, 9 showed an increased number of MPO deficient PMN. Complete remission was attained in 4 of these, in 3 the number of abnormal granulocytes changed to normal 7, 7 and 14 days before and in 1 simultaneously with the attainment of complete remission. In the other patients no changes in granulocyte MPO activity occurred during the preremission period. All 20 patients examined during complete remission showed a normal MPO activity in granulocytes. Of eight patients, who at diagnosis had shown abnormal granulocyte MPO activity, three developed relapse. In two of these, an increased number of MPO deficient PMN reappeared two and eight months prior to and in one simultaneous with clinical and laboratory suspicion of relapse. A statistically significant relation between low NAP scores and an increased number of MPO deficient PMN was found (P=0.011). Serial determinations of MPO activities in PMN, although restricted to cases of AML with initially abnormal values, may prove helpful in predicting achievement of complete remission and may furthermore prove to be useful as an indicator of early relapse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00321083
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The prognostic significance of cytological, histological and cytogenetic findings in refractory anaemia (RA) and RA with sideroblasts (1987)
    Springer
    Annals of hematology 54 (1987), S. 231-238 
    Details
    ISSN: 1432-0584
    Keywords: Blast foci ; Clonal cytogenetic abnormalities ; Clonal evolution ; Karyotype shift ; “Myeloblasts” ; Myelodysplastic syndromes ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two independent observers performed a double review of cytological and histological bone marrow material obtained at diagnosis and during follow up in 34 patients with the myelodysplastic syndrome (MDS), subtypes refractory anaemia (RA) and RA with ringed sideroblasts (RA-S) (26 and 8 patients, respectively). Average values were used for the analyses. Data obtained at diagnosis confirmed earlier observations that a worse prognosis was indicated by high blast cell counts (P〈0.01), presence of blast foci and clonal cytogenetic abnormalities (P=0.08). Data obtained during follow up, in addition, showed that an increased probability of progression to FAB-subtype RA with an excess of blasts was related to both the occurrence of blast foci (P〈0.05) and the occurrence of new or additional clonal abnormalities (karyotype shift) (P〈0.01). The relationship between parameters investigated at diagnosis, during follow up, and in the pooled material, points to RA-S being a separate entity having a better prognosis than RA, and further substantiates an earlier observed relationship between blast cell accumulation and the frequency of cytogenetically abnormal metaphases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00594199
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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