ISSN:
1432-0584
Keywords:
Acute myeloid leukemia
;
Acute undifferentiated leukemia
;
Monoclonal antibodies
;
Myeloid-associated antigens
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The reactivity of a panel of monoclonal antibodies was studied in fifty-four cases of acute myeloid (AML) or undifferentiated (AUL) leukemias. Thirty-six antibodies from the Myeloid section of the Second Workshop on Human Leukocyte Differentiation Antigens were used in an indirect immunofluorescence assay. The antibodies could be classified into three groups recognizing respectively granulocytic, monocytic or granulomonocytic leukemias. Most antibodies stained erythroblastic and megakaryoblastic leukemias. In each group, it was possible to define antibodies staining either the less differentiated forms (FAB M 1 and M 5 a) or the more differentiated forms (M 2, M 3, M 4 and M 5 b). Six out of eight AUL were stained by some of the antibodies (mainly from the monocytic group). However, a heterogeneity of stainings in a same blast population was observed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00321031
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