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  • 1
    Electronic Resource
    Electronic Resource
    Pallidotectal projection to the inferior colliculus of the rat (1991)
    Springer
    Experimental brain research 87 (1991), S. 223-226 
    Details
    ISSN: 1432-1106
    Keywords: Globus pallidus ; Inferior colliculus ; Retrograde fluorescent tracer ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After injection of fluorescent tracer into the inferior colliculus (IC), retrogradely labeled cells were observed not only in the temporoauditory cortex (ACx) and the substantia nigra pars lateralis, but also in the globus pallidus (GP). These labeled GP cells were localized exclusively in the caudal portion of the GP, which has been known to project to the ACx. Employing a retrograde fluorescent double labeling technique, the GP-IC neurons were found to be distributed in a separate manner from the GP-ACx neurons within the caudal GP. The present study provides further anatomical evidence that the caudal GP has a functional role in auditory processing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228524
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Anatomical and functional compartmentalization of the subparafascicular thalamic nucleus in the rat (1992)
    Springer
    Experimental brain research 90 (1992), S. 175-179 
    Details
    ISSN: 1432-1106
    Keywords: Inferior colliculus ; Spinal cord ; Retrograde transport ; Tyrosine hydroxylase ; Glutamate decarboxylase ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The localization and the transmitter phenotype of subparafascicular thalamic nucleus (Spf) neurons projecting to the inferior colliculus (IC) and to the spinal cord (Sp) were studied by using a retrograde fluorescent double labeling technique, and a combined technique of retrograde tracing and immunohistochemistry for tyrosine hydroxylase (TH) and glutamate decarboxylase (GAD). The cell population of Spf-IC neurons was totally differentiated from that of Spf-Sp neurons which have been reported to be dopaminergic. The former were densely distributed, small to medium sized cells and localized in the central portion of the Spf, while the latter were sparsely distributed, large cells and localized in the marginal portion of the Spf. Spf-IC neurons were completely devoid of TH immunoreactivity and, instead, approximately half of them showed GAD immunoreactivity. From these findings, it is concluded that the Spf is distinctly compartmentalized by the presence at least two separate neuronal subpopulations, which are distinguishable in terms of their cell size, distribution patterns, transmitter phenotypes and trajectories.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229269
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Development and cell kinetics of colonic tumors induced in mice by dimethylhydrazine (1983)
    Springer
    Journal of cancer research and clinical oncology 105 (1983), S. 148-157 
    Details
    ISSN: 1432-1335
    Keywords: Dimethylhydrazine ; Adenoma ; Carcinoma ; Cell kinetics ; Histogenesis ; Colon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Colonic adenomas and carcinomas were induced in mice by intermittent injections of 1,2-dimethylhydrazine for 30 weeks and cell kinetic characteristics of different tumor types were studied by 3H-thymidine autoradiography. Labeling indices of adenomas and several carcinoma types after a single injection of 3H-thymidine were similar, both showing about 20%–23%. There was a tendency for the small adenomas and the poorly differentiated carcinomas to show higher labeling indices than the large adenomas and the well differentiated adenocarcinomas, respectively. By repeated injections of 3H-thymidine, it was shown that all adenoma and carcinoma cells became labeled within 60–70 h after the start of the injections, thereby suggesting a large growth fraction of the DMH-induced adenomas and carcinomas in the mouse colon. No remarkable differences in the labeling patterns were found between the adenomas and carcinomas, on the one hand, and intramucosal carcinomas and invasive carcinomas, on the other. The growth rate of the small adenomas appeared to be greater than that of the large adenomas and the poorly differentiated carcinomas may grow more rapidly than the well differentiated adenocarcinomas. The squamous-cell carcinomas arising in the anal region were shown to grow more rapidly than the adenocarcinomas of the colon. The changing patterns of tumor development were also studied at various times after DMH treatment with special reference to the minute neoplasms and their histogenesis and it was shown that the adenoma cells arising in the crypts accumulate in the upper part of the crypt to form an aberrant proliferative focus from which a neoplasm develops by expansion. The lesions considered to be benign on histological grounds may possibly change into adenocarcinomas of a well differentiated type. The poorly differentiated carcinomas were suggested to arise as de novo malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406925
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    Paper (German National Licenses)
    Fulltext
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